21.01.2013

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Announcements / Press Releases

Campaign gets ready to kick malaria out at the 2013 Africa Cup of Nations [RBM UAM] — (English)
As millions get excited about this year’s 2013 Orange Africa Cup of Nations (AFCON) that will kick off tomorrow, "United Against Malaria" - a powerful campaign driven by Roll Back Malaria Partners – joins forces with African football stars and heads of state to distribute life-saving malaria prevention and treatment messages throughout the tournament...

Twenteeth MERG Meeting [RBM MERG] — (English)
Strengthening the capacity of countries to conduct monitoring and evaluation of malaria in different transmission settings was at the heart of a two-day meeting of Roll Back Malaria (RBM) partners, participating in RBM’s Malaria Monitoring and Evaluation Reference Group. National malaria programme managers from Zimbabwe, Angola, Mozambique and Swaziland gave updates on ongoing system strengthening efforts. Data collection tools and approaches were reviewed in view of addressing the current and future needs of malaria-endemic countries. A review of global indicators was followed by a discussion of the RBM Progress and Impact Series, launched in 2009 to keep track of the headway countries were making towards the 2015 malaria targets....

Artemisin conference strengthens dialogue within supply chain to maintain malaria medicines on the market [RBM: UNITAID, The Global Fund and the World Health Organisation] — (English)
Aligning the global demand for ACT medicines with the supply of artemisinin will be the commanding theme of a two-day international conference, organized with Roll Back Malaria Partners UNITAID, The Global Fund and the World Health Organisation...

Trapping Malaria Parasites Inside Host Blood Cell Forms Basis for New Class of Drugs, Penn Study Finds [Penn Medicine Press Release] — (English)
One of the most insidious ways that parasitic diseases such as malaria and toxoplasmosis wreak their havoc is by hijacking their host's natural cellular processes, turning self against self. Researchers from the Perelman School of Medicine, University of Pennsylvania and Johns Hopkins University, led by Doron Greenbaum, Ph.D., assistant professor of Pharmacology at Penn, have identified the cell signaling pathway used by these parasites to escape from and destroy their host cells and infect new cells -- pointing the way toward possible new strategies to stop these diseases in their tracks. The study appears in Cell, Host and Microbe...

Training Manual on Malaria Entomology for Entomology and Vector Control Technicians (Basic Level) [RBM VCWG] — (English)
Manual [in English], [in French], [in Portuguese], [in Spanish]...

UNICEF: Health Manager, P-4, Kinshasa, DRC [UNICEF] — (English)
Application deadline: 22 January 2013...

fhi360: Senior Technical Advisor, Malaria [fhi360] — (English)
FHI 360 is looking for candidates for an important position, Senior Technical Advisor, Malaria in the Integrated Health Sciences Department within the Global Health, Population & Nutrition Group. FHI 360 is looking for an accomplished expert in the field of malaria to help lead the development of a malaria portfolio in support of FHI 360’s strategic plan....

B&M Gates Foundation: Deputy Director, Malaria [BMGF] — (English)
Requisition Number 3719BR...

RBM New York, United States of America: External Relations Officer, P3 [RBM] — (English)
Application deadline: 28 January 2013...

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Articles requiring subscription or registration

Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases [Nature Scientific Reports 3, Article number: 1068 doi:10.1038/srep01068] — (English)
Here we report mass spectrometric proof of the conjugation and new chemicals that irreversibly inhibited African malaria mosquito AChE with bimolecular inhibition rate constants...

Impact of Horizontal Approach in Vertical Program: Continuous Quality Improvement of Malaria and Tuberculosis Diagnostic Services at Primary-Level Medical Laboratories in the Context of HIV Care and Treatment Program in Ethiopia [Am J Trop Med Hyg 2013 12-0628] — (English)
The use of standardized tools for continuous quality improvement of laboratory services is crucial to identify service gaps, plan targeted interventions, and prove successes...

Acute and Potentially Life-Threatening Tropical Diseases in Western Travelers--A GeoSentinel Multicenter Study, 1996-2011 [Am J Trop Med Hyg 2013 12-0551] — (English)
We performed a descriptive analysis of acute and potentially life-threatening tropical diseases among 82,825 ill western travelers reported to GeoSentinel from June of 1996 to August of 2011...

Systematic review of current and emerging strategies for reducing morbidity from malaria in sickle cell disease [Trop Med Int Health. 2013 Jan 16. doi: 10.1111/tmi.12056] — (English)
Sickle cell disease (SCD) is a chronic debilitating disorder affecting erythrocytes, which is especially prevalent throughout Sub-Saharan Africa and among individuals of African descent. Because malaria is thought to be a significant cause of morbidity and mortality in patients with SCD, malaria chemoprophylaxis is often recommended for these patients. In SCD, malaria chemoprophylaxis reduces malaria parasite count, anaemia and the need for blood transfusion, and improves clinical outcomes...

Total and putative surface proteomics of malaria parasite salivary gland sporozoites [mcp.M112.024505] — (English)
Here we describe proteomic profiling of highly purified salivary gland sporozoites from two Plasmodium species: human-infective Plasmodium falciparum and rodent-infective Plasmodium yoelii...

Evidence of arbovirus co-infection in suspected febrile malaria and typhoid patients in Nigeria [JIDC] — (English)
The results suggest that misdiagnosis of arbovirus co-infections as malaria infections, combined with a lack of virus surveillance and underreporting of arbovirus infections, increases the potential for undetected and uncontrolled spread of important vector-borne arboviruses becoming serious underlying public health concerns in Nigeria...

Inactivation of Plasmodium spp. in plasma and platelet concentrates using riboflavin and ultraviolet light [Transfusion. 2013 Jan 16. doi: 10.1111/trf.12079] — (English)
Treatment with riboflavin and UV light was effective at reducing viable P. falciparum in both PLT and plasma products by at least 3.2 logs. Additionally, an at least 4.4-log reduction was observed with P. yoelii...

Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies [JEM, doi: 10.1084/jem.20121970] — (English)
Understanding the memory B cell response to natural Pf infection may be key to the development of a malaria vaccine that induces long-lived protection...

Antibodies to E.coli expressed C-terminal domains of Plasmodium falciparum VAR2CSA inhibit binding of CSA-adherent parasites to placental tissue [IAI.00978-12] — (English)
These data support DBL4ϵ and DBL5ϵ as vaccine candidates for pregnancy malaria and demonstrate that E. coli is a feasible tool for the large-scale manufacture of a vaccine based on these VAR2CSA domains...

Defining the timing of action of anti-malarial drugs against Plasmodium falciparum [AAC.01881-12] — (English)
These studies have important implications for further understanding the mechanisms of action of antimalarials, studying and evaluating drug resistance, and the development of new antimalarials...

MDR1- associated resistance to artesunate + mefloquine does not impair blood-stage parasite fitness in a rodent malaria model. [Infection, Genetics and Evolution] — (English)
Here, we undertook a predictive study, using mutant rodent malaria parasites resistant to the Artemisinin combination treatment (ACT) version of artesunate + mefloquine (ATN + MF) to gain insights about their ability to compete with ATN + MF-sensitive forms in untreated hosts. Previously, Plasmodium chabaudi parasites resistant to ATN + MF were selected in vivo through prolonged passaging in mice under increasing doses of the two drugs, and shown to harbour duplication of the mdr1 gene...

Structure of Plasmodium falciparum Thrombospondin-Related Anonymous Protein (TRAP) A domain highlights distinct features in apicomplexan von Willebrand Factor A homologues [Biochem. J. (2013), doi:10.1042/BJ20121058] — (English)
Thrombospondin-related anonymous protein (TRAP), localized in the micronemes and on the surface of sporozoites of infamous malaria parasite Plasmodium, is a key molecule upon infection of mammalian host hepatocytes and invasion of mosquito salivary glands...

Molecular Systematics and Insecticide Resistance in the Major African Malaria Vector Anopheles funestus [Annual Review of Entomology Vol. 58: 393-412 (Volume publication date January 2013) DOI: 10.1146/annurev-ento-120811-153628] — (English)
In this article we examine the progress made on the systematics of the An. funestus group and review research on insecticide resistance and its mechanisms...

Impact of cyfluthrin (Solfac EW050) impregnated bed nets on malaria transmission in the city of Mbandjock: lessons for the nationwide distribution of long-lasting insecticidal nets (LLINs) in Cameroon Parasites & Vectors 2013, 6:10 doi:10.1186/1756-3305-6-10] — (English)
The study confirms the effectiveness of cyfluthrin impregnated nets in reducing malaria transmission. Lessons from this study could be essential to draw guidelines for the management of the recent nationwide distribution of LLINs across Cameroon in 2011...