17.12.2012

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Announcements / Press Releases

New report signals slowdown in the fight against malaria [WHO News release] — (English)
After a rapid expansion of malaria prevention and control programmes between 2004 and 2009, global funding to fight malaria levelled off between 2010 and 2012. According to the World malaria report 2012, a funding slowdown could reverse recent gains in the fight against one of the world’s leading infectious killers...

Un nouveau rapport indique un ralentissement de la lutte antipaludique [Communiqué de presse de l'OMS] — (English)
Après avoir rapidement progressé entre 2004 et 2009, le financement mondial de la prévention et de la lutte antipaludiques s’est stabilisé entre 2010 et 2012. Selon le Rapport 2012 sur le paludisme dans le monde publié aujourd'hui, ces développements indiquent un ralentissement qui risque d'annuler les progrès remarquables récemment accomplis dans la lutte contre l'une des maladies infectieuses les plus meurtrières...

World Malaria Report 2012 [WHO/GMP] — (English)
The World Malaria Report 2012 summarizes information received from 104 malaria-endemic countries and other sources, and updates the analyses presented in the 2011 report. It highlights the progress made towards the global malaria targets set for 2015 and describes current challenges for global malaria control and elimination...

Malaria Consortium's Annual Review for 2011-12 [Malaria Consortium] — (English)
As well as highlighting achievements in the last period, Malaria Consortium’s Annual Review for 2011-12 gives renewed focus to the learning that our staff and projects continue to generate across sub-Saharan Africa and Southeast Asia. That learning has been integral to the development of the organisation and as Malaria Consortium enters its 10th anniversary year, sharing learning and best practice will be at the forefront of our organisational objectives...

Lutherans Take the Fight Against Malaria to Capitol Hill [UN Foundation blog] — (English)
That's what Rogath Lewis Mollel of the Evangelical Lutheran Church in Tanzania (ELCT) said to me as we made our way into the Cannon House Office Building on Capitol Hill...

MALAREO products and Spatial statistics for malaria epidemiology [MALAREO] — (English)
Registration is now open for the 3rd course: Demo of MALAREO products and Spatial statistics for malaria epidemiology...

MMV: MMV: Assessing potential demand for intra-rectal artesunate [MMV] — (English)
Application deadline: 15 January 2013. View the Request for proposals and more info...

MMV: Director, External Relations [MMV] — (English)
Application deadline: 21 December 2012...

PSI: Principal investigator, ACTwatch and diagnostics in private sector research Department: Malaria and Child Survival (MCSD) [PSI] — (English)
To view the job description and apply online, please visit PSI career center...

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Articles requiring subscription or registration

Shape change in the receptor for gliding motility in Plasmodium sporozoites [PNAS] — (English)
Our results provide insights into regulation of "stick-and-slip" parasite motility and for development of sporozoite subunit vaccines...

Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector [PNAS, 2012 201211614] — (English)
Here, we present a thorough structure-and-function analysis of thrombin inhibition by anophelin, including the 2.3-Å crystal structure of the human thrombin·anophelin complex...

Congenital malaria in a European country [BMJ Case Reports 2012; doi:10.1136/bcr-2012-007310] — (English)
A newborn of 26 days, born in Lisbon, Portugal, presented with fever, anaemia and thrombocytopaenia. She was admitted considering neonatal sepsis, but Plasmodium vivax was identified in the second peripheral blood smear performed. Parenteral quinine was started with good evolution. Despite clinicians' unfamiliarity with congenital malaria in non-endemic areas, this diagnosis, although rare, should not be forgotten in the evaluation of newborns/infants born to women from endemic areas or with recent trip to these areas...

Platelet Factor 4 and Duffy Antigen Required for Platelet Killing of Plasmodium falciparum [Science Vol. 338 no. 6112 pp. 1348-1351 DOI: 10.1126/science.1228892] — (English)
The protective function afforded by platelets during a malarial infection may therefore be compromised in Duffy-negative individuals, who do not express Fy....

Injections May Take the Bite Out of Malaria Studies [JAMA. 2012;308(22):2325. doi:10.1001/jama.2012.105690] — (English)
Studies of experimental malaria interventions have long relied on a tried-and-true method of causing malaria infections in healthy volunteers by subjecting them to bites from mosquitos infected with Plasmodium falciparum parasites. But results from a preliminary study presented at the American Society of Tropical Medicine and Hygiene in November suggest that injections of purified cryopreserved P falciparum sporozoites may also do the trick...

Comparison of asymptomatic Plasmodium spp. infection in two malaria-endemic Colombian locations [Trans R Soc Trop Med Hyg (2012) doi: 10.1093/trstmh/trs021] — (English)
Measurement of the prevalence of asymptomatic Plasmodium spp. infection is suggested as part of the epidemiologic evaluation of malaria in low-transmission areas such as Colombia...

Efficacy and safety of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in endemic countries: meta-analysis of randomised controlled studies [Trans R Soc Trop Med Hyg (2012) doi: 10.1093/trstmh/trs019] — (English)
The present review aimed to synthesise available evidence on the efficacy of dihydroartemisinin-piperaquine (DP) in treating uncomplicated Plasmodium falciparum malaria in people living in malaria-endemic countries by performing a meta-analysis of relevant studies...

A community-randomised evaluation of the effect of IPTi on anti-malarial drug resistance in southern Tanzania [ Infect Dis. (2012) doi: 10.1093/infdis/jis742] — (English)
IPTi did not increase drug pressure, or the selection on dhfr and dhps mutants, when SP was first line malaria treatment. Introduction of artemether-lumefantrine was followed by an increase in dhfr mutations, consistent with weak selection attributable to SP-IPTi, but not dhps, suggesting a fitness cost of this mutation...

Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms [J Infect Dis. (2012) doi: 10.1093/infdis/jis747] — (English)
We analysed two clinical trials that assessed the efficacy and effectiveness of artemether-lumefantrine...

The effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based combination therapies in malaria patients from Cambodia and Tanzania [AAC.01700-12] — (English)
It cannot be ruled out that our results represent isolated findings, and therefore more studies, ideally with the same artemisinin-based combination therapies, in different populations are needed to evaluate the influence of pharmacogenetic factors on the clearance of antimalarials...

Status of pyrethroid resistance in Anopheles gambiae s. s. M form prior to the scaling up of Long Lasting Insecticidal Nets (LLINs) in Adzope, Eastern Cote d'Ivoire [Parasites & Vectors 2012, 5:289 doi:10.1186/1756-3305-5-289] — (English)
Prior to LLINs scaling up in Eastern Cote d'Ivoire, resistance was largely present at various levels in An. gambiae. Underlying mechanisms included the high frequency of the L1014F kdr mutation and other unidentified components, probably metabolic detoxifiers. Their impact on the efficacy of the planned strategy (LLINs) in the area should be investigated alongside careful monitoring of the trend in that resistance over time. The need for alternative insecticides to supplement or replace pyrethroids on nets must be stressed...

Targeting apicoplasts in malaria parasites [Informa doi:10.1517/14728222.2013.739158] — (English)
More than a decade of research on the apicoplast has confirmed the promise of this organelle as a source of drug targets. It is now possible to rationally assess the value of existing drugs and new drug targets, and to understand the role these drugs can play in the arsenal of anti-malarial treatments...

Falcipain inhibitors as potential therapeutics for resistant strains of malaria: a patent review [Informa doi:10.1517/13543776.2013.743992] — (English)
It is a known fact that malaria is a serious health problem worldwide due to the emergence of resistant strains. Hence, development of novel, potent and affordable antimalarial drugs devoid of side effects is of great significance and in great demand. FPs, the malarial cysteine proteases are potential targets for development of new antimalarial drugs. Assessing the available literature on FP-2/3 and their inhibitors it could be speculated that these inhibitors have the potential to enter the clinical stages of development for the treatment of malaria in the years to come ...

Efficient depletion of host DNA contamination in malaria clinical sequencing [JCM.02507-12] — (English)
We have developed a simple enzymatic treatment method that takes advantage of the methylation of human DNA to selectively deplete host contamination from clinical samples prior to sequencing...

Spectrum of Illness in International Migrants seen at GeoSentinel Clinics 1997-2009, Part 2: Migrants Resettled Internationally and Evaluated for Specific Health Concerns [Clin Infect Dis. (2012) doi: 10.1093/cid/cis1016] — (English)
Eliciting a migration history is important at every encounter; migrant patients may have acute illness or chronic conditions related to exposure in their country of origin...

Spectrum of Illness in International Migrants seen at GeoSentinel Clinics 1997-2009, Part 1: US Bound Migrants Evaluated by Comprehensive Protocol-Based Health Assessment [Clin Infect Dis. (2012) doi: 10.1093/cid/cis1015] — (English)
These data support recommendations developed in some countries to screen all newly arriving migrants for some specific diseases (such as tuberculosis) and can be used to help in the process of developing additional screening recommendations that might be applied broadly or focused on specific at risk populations...

Isoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum [EC.00073-12] — (English)
These results provide insights to the biological functions of isoprenoids in malaria parasites and may assist the rational selection of secondary agents that will be useful in combination therapy with new isoprenoid biosynthesis inhibitors...