11.02.2013

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Announcements / Press Releases

Africa Cup of Nations ceremony sends life-saving malaria messages to millions [RBM] — (English)
As the 2013 Orange Africa Cup of Nations drew to a close on Sunday evening, United Against Malaria (UAM) - an official social cause of the tournament - kicked off the closing ceremony with a debut performance of "Hearts on Fire" by RBM Goodwill Ambassador and UAM Champion Yvonne Chaka Chaka...

Programmatic Gap Analysis workshop [RBM] — (English)
Programmatic Gap Analysis workshop takes place on 13-15 February 2013 in Nairobi, KENYA...

Major commitment achieved for development of vaccines against pregnancy-associated malaria [EVI] — (English)
€16 million raised with support from European Vaccine Initiative to advance development of vaccines against placental malaria, a major cause of infant and maternal death...

Bill Gates' Annual Letter [BMGF] — (English)
A combination of vaccines, malaria prevention, and improved newborn health care has helped reduce child mortality globally since 1990—progress that brings the world closer to achieving one of the eight Millennium Development Goals...

Malaria protection in pregnancy [RBM] — (English)
A lifesaving intervention for preventing neonatal mortality and low birth weight summarizes the evidence of the protective effect of malaria prevention in pregnancy on neonatal mortality. The brief developed in partnership between PMI, RBM and MCHIP highlights the critical importance of continuing IPTp as well as ITN use among pregnant women to prevent the adverse consequences of malaria in pregnancy...

B&M Gates Foundation: Deputy Director, Malaria [BMGF] — (English)
Requisition Number 3719BR...

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Articles requiring subscription or registration

WHO and the future of disease control programmes [Lancet. 2013 Feb 2;381(9864):413-8. doi: 10.1016/S0140-6736(12)61812-1] — (English)
WHO's traditional role in promoting communicable disease control programmes must also adapt to new circumstances. Among a multiplicity of actors, WHO's task is to enhance its normative role as convenor, coordinator, monitor, and standard-setter, fostering greater coherence in global health...

Immune mechanisms in malaria: new insights in vaccine development [Nature Medicine 19, 168–178 (2013) doi:10.1038/nm.3083] — (English)
Here we briefly review the epidemiological and immunological requirements for malaria vaccines and the recent history of malaria vaccine development and then put forward a manifesto for future research in this area...

Malaria biology and disease pathogenesis: insights for new treatments [Nature Medicine 19, 156–167 (2013) doi:10.1038/nm.3073] — (English)
Our current understanding of the biology of asexual blood-stage parasites and gametocytes and the ability to culture them in vitro lends optimism that high-throughput screenings of large chemical libraries will produce a new generation of antimalarial drugs. There is also a need for new therapies to reduce the high mortality of severe malaria. An understanding of the pathophysiology of severe disease may identify rational targets for drugs that improve survival...

Public health challenges and prospects for malaria control and elimination [Nature Medicine 19, 150–155 (2013) doi:10.1038/nm.3077] — (English)
Addressing these challenges in a comprehensive and timely way will allow us to sustain the gains made so far and make further progress in control and progressive elimination...

Heterogeneity and Changes in Inequality of Malaria Risk after Introduction of Insecticide-Treated Bed Nets in Macha, Zambia [Am J Trop Med Hyg 2013 11-0595] — (English)
The results indicate that substantial heterogeneity in malaria risk exists at local and household levels, and household-level heterogeneity may be influenced by interventions, such as ITNs...

Determinants of Anemia among Preschool Children in Rural, Western Kenya [Am J Trop Med Hyg 2013 12-0560] — (English)
Overall 16.8% of anemia cases were associated with malaria, 8.3% with iron deficiency, and 6.1% with inflammation. Interventions should address malaria, iron deficiency, and non-malarial infections to decrease the burden of anemia in this population...

The Effects of ACT Treatment and TS Prophylaxis on Plasmodium falciparum Gametocytemia in a Cohort of Young Ugandan Children [Am J Trop Med Hyg 2013 12-0654] — (English)
We conducted a longitudinal clinical trial in a cohort of HIV-infected and uninfected children living in an area of high malaria transmission intensity in Uganda...

Treatment practices in patients with suspected malaria in Provincial Hospital of Tete, Mozambique [Transactions RSTMH 10.1093/trstmh/trs012] — (English)
Adherence to malaria test results was good in this reference setting, but antibiotic prescription was relatively frequent in clinically stable non-malaria patients. Optimal management of parasite-negative patients must be further defined along with programmatic deployment of the parasite-based strategy...

Immunology and world health: key contributions from the global community [Annals of the New York Academy of Sciences, DOI: 10.1111/nyas.12035] — (English)
This paper will briefly review some major new international health programs, including the GAVI Alliance; the Global Polio Eradication Initiative; the Global Fund to Fight AIDS, Tuberculosis and Malaria; the President's Emergency Plan for AIDS Relief; and the Global Malaria Action Plan...

The Epidemiology of Plasmodium vivax [Adv. Parasitology, Volume 81, Pages 1-267 (2013)] — (English)
Edited by S.I. Hay, Ric Price and J. Kevin Baird.ISBN: 978-0-12-407826-0...

The ongoing quest for malaria vaccines [The Lancet Infectious Diseases, Volume 13, Issue 1, Pages 21 - 22] — (English)
Seen by many as the best hope of eradicating the otherwise intractable scourge of sub-Saharan Africa, an effective malaria vaccine remains elusive. Peter Hayward investigates...

Ketoconazole, a cytochrome P450 inhibitor can potentiate the antimalarial action of α/β arteether against MDR P. yoelii nigeriensis [Acta Tropica] — (English)
The present communication deals with antimalarial potential of a new combination comprising of ketoconazole (KTZ) (an antifungal/inhibitor of CYP3A4) and artemisinin derivative α/β arteether (ART)...

Biosensor as a molecular malaria differential diagnosis [Clinica Chimica Acta] — (English)
This study applied the biosensor technology based on quartz crystal microbalance (QCM) to differentially diagnose the most common and severe malaria, Plasmodium falciparum and Plasmodium vivax...

Features of autophagic cell death in Plasmodium liver-stage parasites [Autophagy. 2013 Feb 6;9(4)] — (English)
Here we suggest that all three types of cell death occur in Plasmodium liver-stage parasites...

A Thrombospondin Structural Repeat Containing Rhoptry Protein from Plasmodium falciparum Mediates Erythrocyte Invasion [Cell Microbiol. 2013 Feb 6. doi: 10.1111/cmi.12118] — (English)
In this study we have characterized the functional role of a TSR containing blood stage protein referred to as P. falciparum thrombospondin related apical merozoite protein (PfTRAMP)...

Multidrug-resistant gram-negative bacteria colonization of healthy US military personnel in the US and Afghanistan [BMC Infectious Diseases 2013, 13:68 doi:10.1186/1471-2334-13-68] — (English)
This study evaluates the prevalence of MDR GNB colonization in US military personnel...

PROMOTER POLYMORPHISMS IN THE ATP BINDING CASSETTE TRANSPORTER GENE INFLUENCES PRODUCTION OF CELL DERIVED MICROPARTICLES AND ARE HIGHLY ASSOCIATED TO SUSCEPTIBILITY TO SEVERE MALARIA IN HUMAN [doi: 10.1128/​IAI.01175-12] — (English)
We report for the first time, an association of ABCA1 promoter polymorphisms with susceptibility to severe malaria, especially to CM and MOD, indicating the protective effect of the mutant variant of the polymorphism. We hypothesise that the -477T and -320G polymorphism affect the downregulation of MP efflux and may be a predictor of organ complication during falciparum malaria infection...

Circulatory hepcidin is associated with the anti-inflammatory response but not with iron or anemic status in childhood malaria [Blood February 4, 2013 blood-2012-10-461418] — (English)
Here we report that hepcidin levels are lower in children with SMA or with CM than those with milder outcome (UM)...

Profiling primaquine metabolites in primary human hepatocytes using UHPLC-QTOF-MS with (13) C stable isotope labeling [J Mass Spectrom. 2013 Feb;48(2):276-85. doi: 10.1002/jms.3122] — (English)
hese findings shed additional light on the human hepatic metabolism of PQ, and the method can be applied for identification of reactive PQ metabolites generated in vivo in preclinical and clinical studies...

The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial [Trials 2013, 14:36 doi:10.1186/1745-6215-14-36] — (English)
This study aims to provide direct evidence for a community effect of hotspot-targeted interventions...