4.02.2013

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Announcements / Press Releases

AMP zeros in on continued net distribution in malaria-endemic countries [AMP] — (English)
As funding shortages slow down the distribution of life-saving mosquito nets in a number of African countries, the Alliance for Malaria Prevention (AMP) is convening members of the RBM Partnership to strategize how to ensure the continued flow of nets to endemic areas. Discussions will focus around improving efficiency gains, extending net durability and planning for providing optimal international support to malaria control programmes in countries. RBM Partner institutions will identify needs in countries and coordinate roles and responsibilities...

RBM to back better malaria vector control in endemic countries [RBM VCWG] — (English)
A two-day annual meeting of the Vector Control Working Group at the Roll Back Malaria Partnership (RBM) spotlights the latest evidence on effective malaria vector control management and provides RBM partners with a platform to develop plans for supporting effectively country efforts in 2013. Topical issues for discussions include capacity building for indoor residual spraying (IRS), insecticide resistance and entomological management...

Funding Gaps Threaten Momentum in Malaria Fight, African Leaders Declare [ALMA] — (English)
Recent Nobel Prize laureate, President Ellen Johnson Sirleaf of Liberia, today assumed the chair of the African Leaders Malaria Alliance (ALMA) from President Jakaya Mrisho Kikwete of the United Republic of Tanzania. President Armando Guebuza of Mozambique was elected Deputy Chair of ALMA. ALMA is an alliance of 41 African heads of state and government working to end malaria-related deaths on the continent...

A Community Comes Together to Fight Malaria in Guinea [MSF] — (English)
In Guinea, Doctors Without Borders/Médecins Sans Frontières (MSF) has set up a network of community health agents as part of its strategy to tackle malaria. These volunteers are committed to working for the well-being of their communities...

Malaria consortium launches website linking institutions, researchers, projects [Emory University News and Events] — (English)
A unique malaria systems biology website launched this week will inform the public, scientists, teachers, students and journalists about malaria research and will create new collaborative opportunities for researchers worldwide....

WHO/GMP: Consultant [WHO/GMP] — (English)
GMP is currently looking for a consultant to manage a consultative and inclusive process of developing a plan for the control and elimination of P. vivax which will form an integral part of the Global Technical Strategy for Malaria Control & Elimination, 2016-2025...

MMV: Human Resources Officer [MMV] — (English)
Application deadline: 10 February 2013...

B&M Gates Foundation: Deputy Director, Malaria [BMGF] — (English)
Requisition Number 3719BR...

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Articles requiring subscription or registration

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes [Nature Communications 4, Article number: 1415 doi:10.1038/ncomms2449] — (English)
Here using viable purified Plasmodium falciparum merozoites and three-dimensional structured illumination microscopy, we investigate remodelling events immediately following parasite invasion. We show that multiple complexes of the Plasmodium translocon of exported proteins localize together in foci that dynamically change in clustering behaviour...

Malaria and the conducting system of the heart [BMJ Case Reports 2013; doi:10.1136/bcr-2012-007462] — (English)
We report the case of an adult male patient who was admitted to our hospital with a diagnosis of vivax malaria complicated with renal insufficiency and acute respiratory distress syndrome (ARDS)...

Inter-Relationships of Cardinal Features and Outcomes of Symptomatic Pediatric Plasmodium falciparum Malaria in 1,933 Children in Kampala, Uganda [Am J Trop Med Hyg 2013 12-0668] — (English)
Our report updates previous clinical descriptions of severe malaria, quantifies significant clinical and laboratory inter-relationships, and will assist clinicians treating malaria and those planning or assessing future research...

Cardioacceleratory function of the neurohormone CCAP in the mosquito Anopheles gambiae [J Exp Biol 216, 601-613] — (English)
Here, we determined the CCAP gene structure in the malaria mosquito Anopheles gambiae, assessed the developmental expression of CCAP and its receptor and determined the role that CCAP plays in regulating mosquito cardiac function...

Compliance with antimalarial chemoprophylaxis in German soldiers: a 6-year survey [Infection] — (English)
The study confirms the findings of the French and US armies that even free-of-charge access to antimalarial medication will not lead to 100 % acceptance. The compliance problem is aggravated by the generally low age of deployed soldiers. Adequate counselling is crucial to increase adherence to antimalarial CP...

Malaria Prophylaxis in Patients with Renal Impairment [Drug Safety] — (English)
This review provides recommendations on the use of antimalarial drugs, alone or in combination, in patients with renal impairment...

Specific detection of topoisomerase i from the malaria causing P. falciparum parasite using isothermal Rolling Circle Amplification [Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE] — (English)
We present a Rolling-Circle-Enhance-Enzyme-Activity-Detection (REEAD) system with potential use for future point-of-care diagnosis of malaria...

No evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s [Infection, Genetics and Evolution] — (English)
These results provide insight into the patterns of genetic diversity of saglin and laminin, and we discuss these findings in relation to the potential development of these molecules as vaccine targets...

Perturbations of Plasmodium Puf2 Expression and RNA-seq of Puf2-Deficient Sporozoites Reveal a Critical Role in Maintaining RNA Homeostasis and Parasite Transmissibility [Cellular Microbiology] — (English)
These findings uncover requirements for maintaining a window of opportunity for the malaria parasite to accommodate the unpredictable moment of transmission from mosquito to mammalian host...

Impact of chromosome ends on the biology and virulence of Plasmodium falciparum [Molecular and Biochemical Parasitology] — (English)
Here, we review the current understanding of chromosome ends, the proteins that bind to these regions and their impact on the biology and virulence of P. falciparum...

Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity [Molecular and Biochemical Parasitology] — (English)
We studied the substrate specificity requirements of recombinant cysteine peptidases from Plasmodium falciparum, falcipain-2 (FP-2) and falcipain-3 (FP-3) using fluorescence resonance energy transfer (FRET) peptides as substrates...

Silence, activate, poise, and switch! Mechanisms of antigenic variation in Plasmodium falciparum [Cellular Microbiology] — (English)
In this review we discuss the recent findings in the molecular processes essential for clonal variation, namely silencing, activation, poising, and switching...