03.12.2012

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Announcements / Press Releases

RBM Harmonization Working Group 13th Meeting [RBM HWG] — (English)
The Harmonization Working Group (HWG), a mechanism of the Roll Back Malaria Partnership, convened priority malaria-endemic countries and their international partners to review country needs for technical and financial support and assess the implications of the current funding gap, the changes in the Global Fund and the new funding modalities. Participants will agree on priorities and activities for 2013...

Princess Astrid of Belgium and Dr Nafo-Traoré visit the Institute of Tropical Medicine in Anvers [RBM] — (English)
Princess Astrid of Belgium, a goodwill ambassador of the Roll Back Malaria Partnership, and Dr. Nafo-Traoré, RBM Executive Director visited on Wednesday the Institute of Tropical Medicine (ITM) in Anvers. They were received by Cathy Berx, governor of the province of Anvers and Bruno Gryseels, Director of the ITM. The working meeting concluded with a presentation on the ongoing malaria control efforts before a student audience...

Rising malaria health threat for Congolese refugees in Uganda [UNHCR] — (English)
After surviving the trauma of forced displacement and insecurity, thousands of Congolese refugees are facing a new and potentially fatal danger in Uganda – malaria...

Mosquitoes as involuntary bioterrorists [Vanderbild University News] — (English)
For many years scientists thought that mosquitoes provided the disease organisms which they spread with a relatively free ride because the insects didn't have much in the way of natural defenses to fight off these microscopic stowaways...

Roadmap Tracking Tool - User Guide [RBM] — (English)
A simple guidance document for the use of the USB-key based Roadmap tracking tool...

FEUILLE DE ROUTE – OUTIL DE SUIVI [RBM] — (French)
Un guide simple pour l’utilisation de l’Application sur clé USB...

PSMWG meetings documents [RBM] — (English)
Ninth PSMWG Meeting and Workshop on Resolving PSM Bottlenecks for Malaria Health Products...

ARTEMISININ CONFERENCE 2013 [RBM/The Global Fund/UNITAID/WHO] — (English)
The next Artemisinin Conference will be held at the Windsor Hotel & Country Club, Nairobi, Kenya on the 15th/16th January 2013...

MMV: Director, External Relations [MMV] — (English)
Application deadline: 21 December 2012...

PSI: Principal investigator, ACTwatch and diagnostics in private sector research Department: Malaria and Child Survival (MCSD) [PSI] — (English)
To view the job description and apply online, please visit PSI career center...

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Articles requiring subscription or registration

Insulator-like pairing elements regulate silencing and mutually exclusive expression in the malaria parasite Plasmodium falciparum [PNAS] — (English)
We have identified and characterized insulator-like DNA elements that are required for pairing var promoters and introns and thus are essential for regulating silencing and mutually exclusive expression...

Primaquine to prevent transmission of falciparum malaria [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(12)70198-6] — (English)
The addition of one dose of primaquine to artemisinin-based combination regimens could help to counter the spread of artemisinin resistance. Although primaquine is commonly recommended for falciparum and vivax malaria, concerns about drug-related haemolysis frequently prevent its administration. The limited available evidence on transmission-blocking effects of primaquine and its forerunner plasmoquine suggests that doses lower than currently recommended (0·50—0·75 mg base per kg), which would be safer, might still be very effective...

Antiretroviral Agents and Prevention of Malaria in HIV-Infected Ugandan Children [N Engl J Med 2012; 367:2110-2118November 29, 2012DOI: 10.1056/NEJMoa1200501] — (English)
We hypothesized that the incidence of malaria in HIV-infected children would be lower among children receiving lopinavir–ritonavir–based antiretroviral therapy (ART) than among those receiving nonnucleoside reverse-transcriptase inhibitor (NNRTI)–based ART...

Malaria mortality estimates: need for agreeable approach [Tropical Medicine & International Health DOI: 10.1111/tmi.12020] — (English)
The purpose of this commentary is to shed light on ways to ensure that we do not continue to have this dichotomy in malaria mortality estimates in the future...

Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria [Tropical Medicine & International Health DOI: 10.1111/tmi.12028] — (English)
The results lend support to concerns that IPTp use may lead to increased drug resistance in pregnant women during pregnancy and emphasise the importance of screening pregnant women for malaria parasites in areas with prevalent SP resistance even when they are already on IPTp...

Malaria and the heart [BMJ Case Reports 2012; doi:10.1136/bcr-2012-007275] — (English)
Unusual association of diseases/symptoms...

A scoping review of malaria forecasting: past work and future directions [BMJ Open 2012;2:e001992 doi:10.1136/bmjopen-2012-001992] — (English)
Applying different forecasting methods to the same data, exploring the predictive ability of non-environmental variables, including transmission reducing interventions and using common forecast accuracy measures will allow malaria researchers to compare and improve models and methods, which should improve the quality of malaria forecasting...

Characterization of the Plasmodium falciparum Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase Gene in Samples from Equatorial Guinea before Implementation of Artemisinin-Based Combination Therapy [Am J Trop Med Hyg 2012 12-0364 doi: 10.4269/ajtmh.2012.12-0364] — (English)
The purpose of this study was to determine the prevalence of single-nucleotide polymorphisms (SNPs) in pfatp6...

NF135.C10: a new Plasmodium falciparum clone for controlled human malaria infections [J Infect Dis. (2012) doi: 10.1093/infdis/jis725] — (English)
We established a new field clone of Plasmodium falciparum (Pf) for use in controlled human malaria infections (CHMI) and vaccine studies to complement the current small portfolio of Pf strains, primarily based on NF54...

Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins [mcp.M112.021238 doi: 10.1074/mcp.M112.021238] — (English)
We have applied proteomic, genomic and reverse-genetic approaches to identify P. berghei proteins potentially involved in transport of proteins to the irbc surface...

IDENTIFICATION OF A POTENT COMBINATION OF KEY PLASMODIUM FALCIPARUM MEROZOITE ANTIGENS THAT ELICIT STRAIN TRANSCENDING PARASITE NEUTRALIZING ANTIBODIES [AI.01107-12 doi: 10.1128/​I] — (English)
We have thus demonstrated a novel two-step screening approach to identify a potent antigen combination that elicits strong strain-transcending invasion inhibition supporting its development as a receptor-blocking malaria vaccine...

The population pharmacokinetic and pharmacodynamic properties of intramuscular quinine in Tanzanian children with severe falciparum malaria [​AAC.01349-12 doi: 10.1128/​AAC.01349-12] — (English)
Intramuscular quinine is rapidly and reliably absorbed in children with severe falciparum malaria. Based on these pharmacokinetic data, a loading of 20 mg salt/kg is recommended, provided no loading dose was administered within 24 hours and no routine dose within 12 hours of admission..

Crowdsourcing malaria parasite quantification: an online game for analyzing images of infected thick blood smears [J Med Internet Res. 2012 Nov 29;14(6):e167. doi: 10.2196/jmir.2338] — (English)
This research tests the feasibility of a crowdsourced approach to malaria image analysis. In particular, we investigated whether anonymous volunteers with no prior experience would be able to count malaria parasites in digitized images of thick blood smears by playing a Web-based game...

Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum [Genome Biology 2012, 13:R108 doi:10.1186/gb-2012-13-11-r108] — (English)
Our study provides comprehensive new insight into the biology of the Plasmodium nucleus and will serve as an important platform for dissecting general and parasite-specific nuclear processes in malaria parasites...

Modeling the evolution of drug resistance in malaria [Journal of Computer-Aided Molecular Design November 2012] — (English)
Here we study the amino acid replacements in dihydrofolate reductase (DHFR) that confer resistance to pyrimethamine while still binding the natural DHFR substrate, 7,8-dihydrofolate, and cofactor, NADPH...

Uncomplicated malaria among pregnant women in the Brazilian Amazon: Local barriers to prompt and effective case management [Acta Tropica] — (English)
This study, conducted between the first bimesters of 2007 and 2008, aims to identify the local barriers to prompt and effective case management of malaria in pregnancy and was carried out in health facilities located in three endemic municipalities of the Brazilian Amazon (Manaus, Presidente Figueiredo and Porto Velho). The study design combined both qualitative and quantitative descriptive methods...

Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors [J. Med. Chem., Just Accepted Manuscript DOI: 10.1021/jm301506h] — (English)
Herein, we disclosed the structure-activity relationships of a selective family of hydroxamate PfAM1 inhibitors based on the malonic template...

Reduction of malaria transmission by transgenic mosquitoes expressing an antisporozoite antibody in their salivary glands [Insect Molecular Biology DOI: 10.1111/j.1365-2583.2012.01168.x] — (English)
These results suggest that salivary gland-specific expression of antisporozoite molecules could be a promising strategy for blocking malaria transmission to humans...