26.11.2012

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Announcements / Press Releases

RBM briefs Ministers attending WHO Regional Committee for Africa [RBM] — (English)
Representatives of nine central-African governments participated in the expert briefing that the Partnership organized on the side-lines of this assembly (Angola, Cameroun, CAR, Chad, Congo, DR Congo, Gabon, Equatorial Guinea, Sao Tome & Principe)...

6th Meeting of Continuous LLIN Distribution Systems Work Stream [RBM VCWG] — (English)
Background documents and presentations...

East Asia leaders agree to malaria alliance [AusAID Press release] — (English)
East Asian leaders have agreed to form an alliance with Pacific nations to accelerate the fight against malaria and overcome the emergence of drug-resistant strains of the disease. Policymakers adopted an Australian initiated declaration, committing countries to working collaboratively to address malaria control and resistance to antimalarial medicines. The Alliance will assist the implementation of this commitment...

$19.4 million contract establishes malaria research consortium [Emory University News and Events] — (English)
The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded a five-year contract up to $19.4 million, depending on contract options exercised, to establish the Malaria Host-Pathogen Interaction Center (MaHPIC). The consortium includes researchers at Emory University, with partners at the University of Georgia (UGA), the Georgia Institute of Technology (Georgia Tech) and the Centers for Disease Control and Prevention (CDC). The Yerkes National Primate Research Center of Emory University will administer the contract...

Disc-shaped Point-of-Care platform for infectious disease diagnosis / DiscoGnosis [Institut für Mikrosystemtechnik – IMTEK Albert-Ludwigs-Universität Freiburg] — (English)
A team of researchers aims to develop a rapid test of this kind within the context of the project DiscoGnosis. Launched in November 2012, the project will receive three million euros in funding from the European Union and is being coordinated by the Department of Microsystems Engineering (IMTEK) of the University of Freiburg...

Friends Africa Newsletter [Friends Africa] — (English)
November issue...

MMV: Director, External Relations [MMV] — (English)
Application deadline: 21 December 2012...

PSI: Principal investigator, ACTwatch and diagnostics in private sector research Department: Malaria and Child Survival (MCSD) [PSI] — (English)
To view the job description and apply online, please visit PSI career center...

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Articles requiring subscription or registration

Alterations in Plasmodium falciparum Genetic Structure Two Years after Increased Malaria Control Efforts in Western Kenya [Am J Trop Med Hyg 2012 12-0308] — (English)
he genetic structure of the parasite population was assessed by using microsatellites, and the prevalence of drug-resistant mutations was examined by using the polymerase chain reaction–restriction fragment length polymorphism method...

Seasonal Differences in Retinopathy-Negative versus Retinopathy-Positive Cerebral Malaria [Am J Trop Med Hyg 2012 12-0415] — (English)
We retrospectively reviewed the seasonal pattern of retinopathy status in patients admitted with CM in Blantyre, Malawi from 1997 to 2010...

Birthweight in Offspring of Mothers with High Prevalence of Helminth and Malaria Infection in Coastal Kenya [Am J Trop Med Hyg 2012 12-0371] — (English)
The high prevalence of maternal infection coupled with a higher than expected percentage of LBW highlight a need for further investigation of the association of maternal co-infection with LBW...

Lessons from malaria control to help meet the rising challenge of dengue [The Lancet Infectious Diseases, Volume 12, Issue 12, Pages 977 - 984, December 2012 doi:10.1016/S1473-3099(12)70246-3] — (English)
Achievements in malaria control could inform efforts to control the increasing global burden of dengue...

The treatment of imported malaria in children: an update [Arch Dis Child Educ Pract Ed doi:10.1136/archdischild-2011-301530] — (English)
This review discusses these new data and expands the scope of the previous review to include non-endemic countries outside of the UK...

The effect of primaquine on gametocyte development and clearance in the treatment of uncomplicated falciparum malaria with dihydroartemisinin-piperaquine in South Sumatra, Western Indonesia: an open label randomized controlled trial [Clin Infect Dis. (2012) doi: 10.1093/cid/cis959] — (English)
A 2-arm randomized controlled trial conducted in Indonesia showing that the addition of a single dose of primaquine (0.75 mg/kg) shortens the infectivity period of malaria patients treated with dihydroartemisinin-piperaquine with normal glucose-6-phosphate dehydrogenase (G6PD) enzyme levels...

Effect of high dose or split dose artesunate on parasite clearance in artemisinin resistant falciparum malaria [Clin Infect Dis. (2012) doi: 10.1093/cid/cis958] — (English)
New treatment strategies are needed for artemisinin resistant falciparum malaria. This randomized trial shows that neither increasing nor splitting the standard once daily artesunate dose reverses the markedly reduced parasite clearance rate in patients with artemisinin resistant falciparum malaria...

Single dose primaquine as gametocytocidal treatment in patients with uncomplicated falciparum malaria [Clin Infect Dis. first published online November 21, 2012 doi:10.1093/cid/cis962] — (English)
The world has seen a significant reduction in the burden of falciparum malaria over the last decade which can to a large extent be attributed to the wide deployment of insecticide treated bed nets and the introduction of the highly effective artemisinin combination therapies...

Single dose primaquine as gametocytocidal treatment in patients with uncomplicated falciparum malaria [Clin Infect Dis. first published online November 21, 2012 doi:10.1093/cid/cis962] — (English)
The world has seen a significant reduction in the burden of falciparum malaria over the last decade which can to a large extent be attributed to the wide deployment of insecticide treated bed nets and the introduction of the highly effective artemisinin combination therapies...

Salinity-tolerant larvae of mosquito vectors in the tropical coast of Jaffna, Sri Lanka and the effect of salinity on the toxicity of Bacillus thuringiensis to Aedes aegypti larvae [Parasites & Vectors 2012, 5:269 doi:10.1186/1756-3305-5-269] — (English)
A variety of mosquito vectors of human diseases undergo pre-imaginal development in brackish or saline waters in coastal areas of the Jaffna district in northern Sri Lanka. Salinity has a small but significant negative impact on the toxicity of B. thuringiensis toxin to Ae. aegypti larvae at salinity levels where Ae. aegypti larvae are found in the environment. This has implications for the use of B. thuringiensis toxin as a larvicide in brackish waters...

Corporate philanthropy and conflicts of interest in public health: ExxonMobil, Equatorial Guinea, and malaria [Journal of Public Health Policy doi:10.1057/jphp.2012.60] — (English)
Equatorial Guinea, the most prosperous country in Africa, still bears a large malaria burden. With massive wealth from oil reserves, and nearly half its population living in island ecotypes favourable for malaria control, only poor governance can explain continued parasite burden. By financially backing the country's dictator and other officials through illicit payments, the oil company ExxonMobil contributed to the state's failure. Now ExxonMobil, having helped perpetuate malaria in Equatorial Guinea, gives money to non-governmental organizations, charitable foundations, and universities to advocate for and undertake malaria work. How, and on what terms, can public health engage with such an actor? We discuss challenges in the identification and management of conflicts of interest in public health activities. We reviewed the business and foundation activities of ExxonMobil and surveyed organizations that received ExxonMobil money about their conflict of interest policies. Reforms in ExxonMobil's business practices, as well as its charitable structure, and reforms in the way public health groups screen and manage conflicts of interest are needed to ensure that any relationship ultimately improves the health of citizens...

Reduced Plasmodium berghei sporozoite liver load associates with low protective efficacy after intradermal immunization [Parasite Immunology Volume 34, Issue 12, pages 562–569, December 2012] — (English)
Protection against sporozoite infection is likely dependent on parasite liver infection and subsequently generated cellular immune responses...

Evidence from NMR interaction studies challenges the hypothesis of direct lipid transfer from L-FABP to malaria sporozoite protein UIS3 [Protein Science DOI: 10.1002/pro.2194] — (English)
The present investigation entails a reformulation ofthe current model of host-pathogen lipid transfer, possibly redirecting researchfor early intervention against malaria...

Larval density dependence in Anopheles gambiae s.s., the major African vector of malaria [Journal of Animal Ecology] — (English)
Anopheles gambiae sensu stricto is the most important vector of malaria in Africa although relatively little is known about the density-dependent processes determining its population size...