19.11.2012

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Announcements / Press Releases

Ninth Procurement and Supply Chain Management Working Group (PSMWG) Meeting [RBM PSMWG] — (English)
Agenda of the meeting...

RBM welcomes Mark Dybul as new Global Fund Executive Director [RBM Statement] — (English)
The RBM Partnership welcomes the appointment of Ambassador Mark Dybul as the new Executive Director of the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund)...

Global Fund Appoints Mark Dybul as Executive Director [Global Fund News Release] — (English)
The Board of the Global Fund to Fight AIDS, Tuberculosis and Malaria today appointed as its new Executive Director Ambassador Mark R. Dybul, a former United States Global AIDS Coordinator...

Board Approves Integration of AMFm into Core Global Fund Grant Process [Global Fund News Release] — (English)
The Global Fund Board decided to integrate the Affordable Medicines Facility - malaria (AMFm) into core Global Fund grant management and financial processes, following an orderly transition period in 2013. The decision was reached after extensive consultations with implementers, technical partners and donors about lessons learned from a pilot phase of AMFm...

Global Fund Board Decides on Transition to New Approach for Funding Grants [Global Fund News Release] — (English)
The Board of the Global Fund to Fight AIDS, Tuberculosis and Malaria today voted to start an immediate transition to a new approach to funding grants by investing additional money in health programs that are poised to achieve the quickest impact...

New global subsidy that provides access to most effective malaria drugs shows promise [ULCA] — (English)
UCLA infectious diseases doctor played key role in finance strategy for therapy...

Community health workers help reduce child deaths in Africa, new evidence shows [RBM] — (English)
Comprehensive evidence has been published that shows how using community health workers to diagnose and treat the three most common killers of African children - pneumonia, diarrhoea and malaria - can increase access and reduce deaths...

PATH's Kent Campbell honored for lifetime achievement in the fight against malaria [PATH Press Release] — (English)
Kent Campbell, PATH's Malaria Control Program director, today received the distinguished Joseph Augustin LePrince Medal in recognition of outstanding work in the field of malariology at the American Society of Tropical Medicine and Hygiene's award ceremony. Through a career spanning more than three decades, Campbell's leadership contributed to enormous progress in the fight against malaria in Africa—where more than 90 percent of malaria deaths occur—paving the way for countries that were once endemic to now strive for eliminating the disease...

Friends Africa Wins Three Stevies at the Stevie Awards in New York [Friends Africa Press Release] — (English)
Friends Africa has emerged Gold Stevie winner of the organisation of the year award in the Non Governmental and Non-profit category at the Stevie Awards dinner in New York. The organisation’s CEO Dr Akudo Ikemba has been named Social Entrepreneur of the year and Female Innovator of the year in Europe, Middle East and Africa clinching Gold and Silver Stevies respectively...

USAID Global Health Fellows Program II: Senior Malaria Technical Advisor [PSI] — (English)
To view the job description and apply online, please visit GHFP net...

PSI: Principal investigator, ACTwatch and diagnostics in private sector research Department: Malaria and Child Survival (MCSD) [PSI] — (English)
To view the job description and apply online, please visit PSI career center...

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Articles requiring subscription or registration

Geographical concentration of falciparum malaria treated in the UK and delay to treatment with artesunate in severe cases: an observational study [BMJ Open 2012;2:e001854 doi:10.1136/bmjopen-2012-001854] — (English)
Geographical location of falciparum cases notified in the UK. Diagnosis-to-treatment times for intravenous artesunate...

Malaria vaccine trial shows lower efficacy in younger than in older infants [BMJ 2012; 345 doi: http://dx.doi.org/10.1136/bmj.e7665] — (English)
A candidate malaria vaccine has produced disappointing results, showing lower efficacy in young babies than it does in older infants, the latest trial data show...

Controlled Human Malaria Infections by Intradermal Injection of Cryopreserved Plasmodium falciparum Sporozoites [Am J Trop Med Hyg 2012 12-0613] — (English)
We assessed in an open label phase 1 trial, infection after intradermal injection of respectively 2,500, 10,000, or 25,000 aseptic, purified, vialed, cryopreserved Pf sporozoites (PfSPZ) in three groups (N = 6/group) of healthy Dutch volunteers. Infection was safe and parasitemia developed in 15 of 18 volunteers (84%), 5 of 6 volunteers in each group...

UK investments in global infectious disease research 1997—2010: a case stud [The Lancet Infectious Diseases, doi:10.1016/S1473-3099(12)70261-X] — (English)
Research funding has to be aligned with prevailing and projected global infectious disease burden. Funding agencies and industry need to openly document their research investments to redress any inequities in resource allocation...

The absence of endemic malaria transmission in Taiwan from 2002 to 2010: The implications of sustained malaria elimination in Taiwan [Travel Medicine and Infectious Disease] — (English)
The purpose of this study was to assess the epidemiology of malaria in Taiwan between 2002 and 2010...

Mosquito ecology and control of malaria [Journal of Animal Ecology DOI: 10.1111/1365-2656.12003] — (English)
Vector control is applied population biology, and I argue here that further progress will require as much attention to mosquito ecology as has been paid to mosquito molecular biology...

Anopheles salivary gland proteomes from major malaria vectors [BMC Genomics 2012, 13:614 doi:10.1186/1471-2164-13-614] — (English)
This is the first report on the diversity of the salivary protein repertoire among species from the Anopheles genus at the protein level. This work demonstrates that a molecular diversity is exhibited among salivary proteins from closely related species despite their common pharmacological activities...

Morphometrical diagnosis of the malaria vectors Anopheles cruzii, An. Homunculus and An. Bellator [Parasites & Vectors 2012, 5:257 doi:10.1186/1756-3305-5-257] — (English)
Our objective was to assess wing geometry to distinguish An. cruzii, An. homunculus and An. bellator...

Malaria transmission after five years of vector control on Bioko Island, Equatorial Guinea [Parasites & Vectors 2012, 5:253 doi:10.1186/1756-3305-5-253] — (English)
The Bioko Island Malaria Control Project (BIMCP) started in 2004 with the aim to reduce malaria transmission and to ultimately eliminate malaria. While the project has been successful in reducing overall malaria morbidity and mortality, foci of high malaria transmission still persist on the island. Results from the 2009 entomological collections are reported here...

Mitochondrial peroxidase TPx-2 is not essential in the blood and insect stages of Plasmodium berghei [Parasites & Vectors 2012, 5:252 doi:10.1186/1756-3305-5-252] — (English)
We sought to identify the cellular function of thioredoxin peroxidase-2 (TPx-2), which is expressed in the mitochondria, by disrupting the TPx-2 gene (pbtpx-2) of the rodent malaria parasite Plasmodium berghei...

Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA [Hum Vaccin Immunother. 2012 Nov 1;8(11)] — (English)
This trial demonstrated the MuStDO5 DNA and hGM-CSF plasmids to be safe and modestly immunogenic for T cell responses. It also laid the foundation for priming with DNA plasmids and boosting with recombinant viruses, an approach known for nearly 15 y to enhance the immunogenicity and protective efficacy of DNA vaccines...

Mechanism-based model of parasite growth and dihydroartemisinin pharmacodynamics in murine malaria [AAC.01463-12] — (English)
The aim of this study was to develop a mechanism-based growth model (MBGM) for P. berghei, and then characterize the parasiticidal effect of dihydroartemisinin (DHA) in murine malaria (MBGM-PK-PD)...

Comparative cost models of a liquid nitrogen vapor phase (LNVP) cold chain-distributed cryopreserved malaria vaccine vs. a conventional vaccine [Vaccine] — (English)
A liquid nitrogen vapor phase (LNVP) cold chain model is described. LNVP distribution costs for a cryopreserved malaria vaccine are presented. Costs are compared to conventional 2–8 °C cold chain vaccine distribution. Capital and recurrent costs, and costs for each level and each component are given. Overall 5-year costs for the LNVP and 2–8 °C cold chain models were very similar...

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants [Vaccine] — (English)
Here, we show that a full-length recombinant PfRH5 protein expressed in mammalian cells is biochemically active, as judged by saturable binding to its receptor, basigin, and is able to induce antibodies that strongly inhibit P. falciparum growth and invasion...