12.11.2012

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Announcements / Press Releases

The 1st Meeting Roll Back Malaria Partnership Communication Community of Practice at the Country Level [RBM Web Update] — (English)
National Malaria Control Programs, Partners and Donor Agencies meet to develop a new road map for enhancing the impact of communication in malaria control efforts at the country level...

PAHO commemorates the 6th annual Malaria Day in the Americas [PAHO/WHO] — (English)
Three government-supported anti-malaria programs from Paraguay, Brazil, and Ecuador were named Malaria Champions of the Americas this week for their success in reducing the burden of malaria through improved diagnosis, treatment, and surveillance. The winners were honored during an event marking the 6th annual Malaria Day in the Americas, at the headquarters of the Pan American Health Organization/World Health Organization (PAHO/WHO)...

New Roll Back Malaria Progress & Impact Series Report "Focus on Swaziland" [RBM] — (English)
New report focuses on Swaziland...

Roll Back Malaria highlights the country’s achievements thanks to Global Fund support [The Global Fund Announcement] — (English)
A report released today by Roll Back Malaria details Swaziland’s recent progress controlling malaria and the transition towards elimination. These achievements were made possible due to supplemental resources provided by the Global Fund to Fight AIDS, Tuberculosis and Malaria...

RBM’s Goodwill Ambassador speaks at the World Economic Forum Summit on the Global Agenda [RBM] — (English)
Yvonne Chaka Chaka, RBM’s Goodwill Ambassador, is among the guest lecturers at a World Economic Forum Summit, focused on the role of art, culture and education in propelling societies forward...

RTS,S malaria candidate vaccine reduces malaria by approximately one-third in African infants [PATH press release] — (English)
International African Vaccinology Conference, Cape Town, South Africa, November 9, 2012—Results from a pivotal, large-scale Phase III trial, published online today in the New England Journal of Medicine, show that the RTS,S malaria vaccine candidate can help protect African infants against malaria. When compared to immunization with a control vaccine, infants (aged 6 to 12 weeks at first vaccination) vaccinated with RTS,S had one-third fewer episodes of both clinical and severe malaria and had similar reactions to the injection. In this trial, RTS,S demonstrated an acceptable safety and tolerability profile...

GAVI statement on latest interim trial data on malaria vaccine candidate [GAVI Statement] — (English)
Latest interim trial data on malaria vaccine candidate RTS,S published by Glaxosmithkline and Path malaria vaccine initiative...

Candidate vaccine reduces malaria by approximately one-third in African infants [WellcomeTrust News] — (English)
Results from a large-scale clinical trial, published in the ‘New England Journal of Medicine’, have shown that a new candidate vaccine being developed by GlaxoSmithKline (GSK) can help protect African infants against malaria...

ASTMH 61st Annual Meeting [ASTMH] — (English)
Meeting homepage...

Artemisia annua, Artemisinin, ACTs & Malaria Control in Africa [MMV] — (English)
3rd edition...

Breaking Barriers: A Leap Ahead in Plasmodium Biology [Trends in Parasitology] — (English)
Special Issue about malaria in Trends in Parasitology November Issue...

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Articles requiring subscription or registration

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants [N Engl J Med. DOI: 10.1056/NEJMoa1208394] — (English)
The RTS,S/AS01 vaccine coadministered with EPI vaccines provided modest protection against both clinical and severe malaria in young infants...

Malaria Vaccine Trials — Beyond Efficacy End Points [N Engl J Med. DOI: 10.1056/NEJMe1213392] — (English)
The results of this trial suggest that this candidate malaria vaccine is not ready to become part of the routine panel of infant immunizations. However, this trial did show protection in a subset of children and thus should be used as an opportunity to enlighten researchers regarding the host responses that correlate with vaccine protection...

Use of Community Health Workers for Management of Malaria and Pneumonia in Urban and Rural Areas in Eastern Uganda [Am J Trop Med Hyg 2012 vol. 87 no. 5 Suppl 30-35 ] — (English)
Use of community health workers (CHWs) has been implemented the same way in urban and rural areas despite differences in availability of health providers and sociodemographic characteristics...

Private Sector Drug Shops in Integrated Community Case Management of Malaria, Pneumonia, and Diarrhea in Children in Uganda [Am J Trop Med Hyg 2012 87:92-96; doi:10.4269/ajtmh.2012.11-0791] — (English)
We conducted a survey involving 1,604 households to determine community care-seeking patterns and 163 exit interviews to determine appropriateness of treatment of common childhood illnesses at private sector drug shops in two rural districts of Uganda...

Impact of Community Management of Fever (Using Antimalarials With or Without Antibiotics) on Childhood Mortality: A Cluster-Randomized Controlled Trial in Ghana [Am J Trop Med Hyg 2012 87:11-20; doi:10.4269/ajtmh.2012.12-0078] — (English)
We aimed to evaluate the impact of adding an antibiotic, amoxicillin (AMX) to an antimalarial, artesunate amodiaquine (AAQ + AMX) for treating fever among children 2–59 months of age within the HMM strategy on all-cause mortality. In a stepped-wedge cluster-randomized, open trial, children 2–59 months of age with fever treated with AAQ or AAQ + AMX within HMM were compared with standard care...

Project to increase availability of malaria drug has worked, study finds [BMJ 2012;345:e7451] — (English)
An evaluation of a controversial initiative to broaden access to malaria medicines has found that in pilot studies it rapidly increased the availability and lowered the price of the drugs...

Malaria. As drug pilot wraps up, a lively debate about its future [Science. 2012 Nov 9;338(6108):732-3. doi: 10.1126/science.338.6108.732] — (English)
An unusual economic experiment that kicked off in 2010 has triggered one of the most impassioned debates in malaria control for years. At issue is a new funding mechanism that very few outside the field know or care much about—a "global subsidy" aimed at bringing the best malaria drugs to the patients who need them most by enlisting the private sector...

Hepcidin and the iron-infection axis [Science. 2012 Nov 9;338(6108):768-72. doi: 10.1126/science.1224577] — (English)
We describe how hepcidin integrates signals from diverse physiological inputs, forming a key molecular bridge between iron trafficking and response to infection...

Antimalarial interaction of quinine and quinidine with clarithromycin [Parasitology. 2012 Nov 9:1-8] — (English)
Quinine (QN) and quinidine (QND) have been commonly used as effective and affordable antimalarials for over many years. Quinine primarily is used for severe malaria treatment....

HIV Nonnucleoside Reverse Transcriptase Inhibitors and Trimethoprim-Sulfamethoxazole Inhibit Plasmodium Liver Stages [J Infect Dis. (2012) 206 (11): 1706-1714. doi: 10.1093/infdis/jis602] — (English)
NNRTIs modestly affect liver stage Plasmodium parasites, whereas TMP-SMX prevents patent parasitemia. Because drugs that inhibit liver stages target parasites when they are present in lower numbers, these results may have implications for eradication efforts. Understanding HIV drug effects on Plasmodium liver stages will aid in optimizing treatment regimens for HIV-exposed and HIV-infected infected patients in malaria-endemic areas...

Defining falciparum malaria attributable severe febrile illness in moderate to high transmission settings based on plasma PfHRP2 [The Journal of Infectious Diseases, 10.1093/infdis/jis675] — (English)
Plasma PfHRP2 concentration defines malaria attributable disease and distinguishes severe malaria from coincidental parasitemia in African children in a moderate to high transmission setting...

Microvascular dysfunction in severe Plasmodium falciparum malaria [J Infect Dis. (2012) doi: 10.1093/infdis/jis681] — (English)
By Cunnington AJ, Riley EM, Walther M....

Microvascular dysfunction in severe Plasmodiumfalciparum malaria In response to Cunnington et al [J Infect Dis. (2012) doi: 10.1093/infdis/jis680] — (English)
Letter...

Isolation of erythrocytes infected with viable early stages of Plasmodium falciparum by flow cytometry [Cytometry Part A DOI: 10.1002/cyto.a.22226] — (English)
The described flow cytometry method, based on staining with Vybrant DyeCycle Violet, allows the isolation of viable ring stages of the malarial agent P. falciparum, and thereby provides the basis for new, broad-range molecular investigations of the parasite...

Use of 1 Rapid Diagnostic Tests for Diagnosis of Malaria in the United States [J Clin Microbiol] — (English)
In the September issue, performance of the BinaxNOW Malaria for the diagnosis of malaria in a major U.S. academic medical center was reported...

Haemolysis risk in methylene blue treatment of G6PD-sufficient and G6PD-deficient West-African children with uncomplicated falciparum malaria: a synopsis of four RCTs [Pharmacoepidemiology and Drug Safety DOI: 10.1002/pds.3370] — (English)
MB treatment of malaria in Africa is associated with slightly reduced haemoglobin values in children with a full G6PD defect compared to non-G6PD deficient children. This effect appears to be of limited clinical relevance but needs to be monitored...

Malaria antibody persistence correlates with duration of exposure [Vox Sanguinis DOI: 10.1111/vox.12000] — (English)
Antibody persistence in donors correlates with exposure category, with semi-immune 'Residents' maintaining detectable antibodies significantly longer than non-immune 'Visitors'...

Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-Causing Plasmodium Parasites Based on Enzyme Activity Measurement [ACS Nano] — (English)
We present an attractive new system for the specific and sensitive detection of the malaria-causing Plasmodium parasites...

Gene Gun Immunization to Combat Malaria [Methods in Molecular Biology Volume 940, 2013, pp 269-284] — (English)
Here we describe the procedures involved in making and delivering a pre-clinical malaria DNA vaccine by gene gun as well as the correct approach for the in vivo evaluation of the vaccine...

Analysis of immunogenicity of different protein groups from malaria parasite Plasmodium falciparum [Infection, Genetics and Evolution, Volume 12, Issue 8, December 2012, Pages 1911–1916] — (English)
In this research we checked whether Plasmodium falciparum proteins containing experimentally evident epitopes from the IEDB database are subject to diversifying selection. We also investigated which life stage of this parasite and which proteins are subject to the strongest immune pressure...