25.06.2012
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Announcements / Press Releases
RBM's New Executive Director Appointed [RBM] — (English)
The Roll Back Malaria Partnership (RBM) is pleased to announce the appointment of Dr Fatoumata Nafo Traoré as the new RBM Executive Director. She will take office on 16 July...
Sustained Malaria Financing at Heart of Africa's Development Agenda [RBM Press Release] — (English)
Ministries of Health call upon Ministers of Finance to fill funding gaps...
Le financement durable de la lutte contre le paludisme au cœur de l'agenda de développement de l'Afrique [RBM Press Release] — (French)
Les Ministères de la Santé africains identifient les écarts financiers relatifs à leurs plans nationaux de lutte contre le paludisme et font appel à leurs Ministères des Finances pour l'utilisation des ressources nationales ou autres sources innovantes...
RBM supports African countries to secure funding for malaria control [RBM HWG] — (English)
37 malaria-endemic countries gathered today for a four-day RBM workshop to develop comprehensive malaria programmatic gap analysis and to enhance countries' understanding of the current donor environment...
RBM reviews progress in malaria control in West Africa [RBM WARN] — (English)
Representatives from 15 countries in the RBM West African Regional Network (WARN) gathered today to review progress on RBM country roadmaps and discuss their needs for technical assistance. They also reviewed the new gap analysis methodology, elimination strategies and the need for seasonal malaria chemoprevention. These discussions are taking place in advance of a two-day workshop where funding gaps in countries will be analyzed and new funding opportunities presented...
Actress and Humanitarian Serinda Swan Joins the Fight Against Malaria [Nothing but Nets Press Release] — (English)
As the newest Champion in the fight against malaria, actress and humanitarian Serinda Swan recently joined a delegation from the United Nations Foundation's Nothing But Nets campaign to visit Kakuma Refugee Camp to distribute insecticide-treated bed nets to refugees. The trip was tied to Nothing But Nets' nationwide appeal to send 100,000 bed nets to refugees fleeing violence in South Sudan...
New mechanism speeds up delivery of life-saving nets [MNM Newsroom] — (English)
On HuffingtonPost.com, Malaria No More CEO David Bowen and Goldman Sachs Managing Director Gene Sykes discuss a new innovative finance mechanism to accelerate the delivery of life-saving mosquito nets to families in Africa, helping to save thousands of lives...
WorldWide Antimalarial Resistance Network (WWARN): Data Manager [WWARN] — (English)
Application deadline: 26 June 2012...
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Articles requiring subscription
Malaria Ecotypes and Stratification [Advances in Parasitology, Vol. 78, Amsterdam: The Netherlands, 2012, pp. 97-167] — (English)
This chapter from the book Advances in Parasitology, Vol. 78, © Elsevier is placed on the website of Swiss Tropical and Public Health Institute with permission from the copyright holder for non-commercial and research use only...
Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing [Nature (2012) doi:10.1038/nature11174] — (English)
Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture...
Differential acquisition of human antibody responses to Plasmodium falciparum according to intensity of exposure to Anopheles bites [Trans R Soc Trop Med Hyg. 2012 Jun 19] — (English)
This study evaluates the influence of a hitherto unstudied environmental-epidemiological factor, namely the impact of human exposure to Anopheles bites on the isotype profile of acquired antibody responses to Plasmodium falciparum...
IFN-γ–Producing CD4+ T Cells Promote Experimental Cerebral Malaria by Modulating CD8+ T Cell Accumulation within the Brain [The Journal of Immunology June 20, 2012 1200688] — (English)
It is well established that IFN-γ is required for the development of experimental cerebral malaria (ECM) during Plasmodium berghei ANKA infection of C57BL/6 mice...
Two long non-coding RNMol Biochem Parasitol. 2012 Jun 18As generated from subtelomeric regions accumulate in a novel perinuclear compartment in Plasmodium falciparum [] — (English)
Here, we show that the non-coding subtelomeric region adjacent to virulence genes forms facultative heterochromatin in a cell cycle-dependent manner. We demonstrate that telomere-associated repeat elements (TAREs) and telomeres are transcribed as long non-coding RNAs (lncRNAs) during schizogony...
Population dynamics of Anopheles gambiae s.l. in Bobo-Dioulasso city: bionomics, infection rate and susceptibility to insecticides [Parasites & Vectors 2012, 5:127 doi:10.1186/1756-3305-5-127] — (English)
Over the last ten years, An. arabiensis has become the major malaria vector in Bobo-Dioulasso city where it was formerly present only at low frequency. However, the ecological determinant that enhances the settlement of this species into urban and peri-urban areas of Bobo-Dioulasso remains to be clarified. The impact of the changing An. gambiae s.l. population in this region for vector control including resistance management strategies is discussed...
Water Quality and Anopheles gambiae Larval Tolerance to Pyrethroids in the Cities of Douala and Yaoundé (Cameroon) [Journal of Tropical Medicine Volume 2012 (2012), Article ID 429817, 10 pages doi:10.1155/2012/429817] — (English)
The data suggest a direct correlation between some characteristics from the breeding sites and larval tolerance to pyrethroids...
Revealing mechanisms underlying variation in malaria virulence: effective propagation and host control of uninfected red blood cell supply [Interface] — (English)
Our results demonstrate a role for self-harm in self-defence for hosts and highlight the diversity and modes of virulence of malaria...
Performance of BinaxNOW for diagnosis of malaria in a U.S. hospital [doi: 10.1128/JCM.01013-12] — (English)
These results support the judicious use of BinaxNOW in screening of malaria suspects in non-endemic areas...
A user-friendly software to easily count Anopheles egg batches [Parasites & Vectors 2012, 5:122 doi:10.1186/1756-3305-5-122] — (English)
In this paper we present a newly developed software for high precision automatic egg counting...
Steric–electronic effects in malarial peptides inducing sterile immunity [Biochemical and Biophysical Research Communications] — (English)
Conserved Plasmodium falciparum high activity binding peptides' (HABPs) most relevant proteins involved in malaria parasite invasion are immunologically silent; critical binding residues must therefore be specifically replaced to render them highly immunogenic and protection-inducing...
Estimated Effect of Climatic Variables on the Transmission of Plasmodium vivax Malaria in the Republic of Korea [EHP] — (English)
Our findings suggest that malaria transmission in temperate areas is highly dependent on climate factors. In addition, lagged estimates of the effect of rainfall on malaria are consistent with the time necessary for mosquito development and P. vivax incubation...
Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro [doi: 10.1128/AAC.01061-12] — (English)
Our findings suggest these novel 4-aminoquinolines should be considered for development as potent antimalarials that can be used in combination to treat multidrug resistant P. falciparum and P. vivax...
Lead Optimization of Anti-Malarial Propafenone Analogs [J Med Chem. 2012 Jun 18] — (English)
Careful examination of the bioavailability, pharmacokinetics, toxicology, and efficacy of this series of compounds using rodent models revealed orally bioavailable compounds that are non-toxic and suppress parasitemia in vivo. Although these compounds possess potential for further preclinical development, they also carry some significant challenges...
An all-purpose antimalarial drug target [Cell: Host and Microbe] — (English)
The recent re-emphasis on malaria eradication has made developing drugs that block transmission and terminate latent disease critical. Most drugs do not affect the liver stages—an ability that is crucial to the latter goal. Addressing this problem, Hoepfner et al., 2012 uncover the parasite's lysyl-tRNA synthetase as a druggable target....