27.02.2012

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Announcements / Press Releases

Theme for World Malaria Day 2012: "Sustain Gains, Save Lives: Invest in Malaria" [RBM] — (English)
Every year the malaria community commemorates World Malaria Day on 25 April. The theme for World Malaria Day 2012 - "Sustain Gains, Save Lives: Invest in Malaria" focuses on the critical need for continued investment in malaria control to safeguard the gains that have been made over the past decade and to promote health and development in malaria-endemic countries. RBM Partners are invited to add their own slogan and key messages under this umbrella theme to reflect their areas of engagement and shed light on particular aspects of malaria control.
For more guidance, information and resources visit World Malaria Day 2012 website...


Leadership interview with Dr Awa Marie Coll-Seck [MACEPA] — (English)
Dr Awa Marie Coll-Seck reflects on her tenure as Executive Director of the Roll Back Malaria Partnership...

RBM Procurement & Supply Chain Management Working Group [RBM PSMWG] — (English)
The RBM Procurement & Supply Chain Management Working Group (PSMWG) is gathering today for its 8th international meeting (PSM8) to discuss current and upcoming challenges that should be addressed by the PSMWG in 2012 and 2013. Workplans for each workstream will be developed to increase coordination, avoiding duplication and fill current gaps...

Delivery of child-friendly antimalarial hits the 100 million mark [MMV] — (English)
One hundred million treatments of Coartem® Dispersible (artemether-lumefantrine), an antimalarial developed especially for children with Plasmodium falciparum malaria, have been delivered by Novartis to 39 malaria-endemic countries, Medicines for Malaria Venture (MMV) announced today...

One step closer to blocking the transmission of malaria [MMV] — (English)
Pioneering MMV research published in PLoS Medicine compares the activity of antimalarial medicines at every step of the parasite’s lifecycle...

Pyramax® receives positive opinion from the EMA [MMV] — (English)
This new antimalarial is indicated for P. falciparum and blood stage P. vivax malaria...

The Tanzanian National Voucher Scheme (TNVS): Keeping up with 'Keep-up' - Tanzania [Continuous LLIN Distribution Systems Work Stream of Roll Back Malaria's Vector Control Working Group] — (English)
Continuous LLIN Distribution Lessons in Brief No.5 ...

Logistics, Logistics, Logistics - Malawi [Continuous LLIN Distribution Systems Work Stream of Roll Back Malaria's Vector Control Working Group] — (English)
Continuous LLIN Distribution Lessons in Brief No.4 ...

Accountable Partnership: Singing from the Same Songbook & Knowing the Score - Malawi [Continuous LLIN Distribution Systems Work Stream of Roll Back Malaria's Vector Control Working Group] — (English)
Continuous LLIN Distribution Lessons in Brief No.3 ...

Making it Work: Integrated Supply and Supervision - Kenya [Continuous LLIN Distribution Systems Work Stream of Roll Back Malaria's Vector Control Working Group] — (English)
Continuous LLIN Distribution Lessons in Brief No.2 ...

Making it Work: The Big Picture - Kenya [Continuous LLIN Distribution Systems Work Stream of Roll Back Malaria's Vector Control Working Group] — (English)
Continuous LLIN Distribution Lessons in Brief No.1 ...

RBM P&I Project Manager [RBM] — (English)
Application deadline: 17 March 2012...

Vestergaard Frandsen News Update [Vestergaard Frandsen] — (English)
February issue...

ACT Consortium Policy Liaison Coordinator [Artemisinin Combination Therapy (ACT) Consortium] — (English)
Application deadline: 4 March 2012...

CORE STRUCTURE for training curricula on Integrated Vector Management [WHO] — (English)
The purpose of this document is to provide guidance for WHO regions preparing their own training curriculum for integrated vector management (IVM); it should be adapted to the requirements and conditions of each region....

GUIDANCE on policy-making for Integrated Vector Management [WHO] — (English)
This document is meant to guide people in an advisory or decision-making role in formulating policy on the control of vector-borne diseases. It was prepared at the same time as a handbook on integrated vector management (IVM), which contains background information and lays out a comprehensive operational framework for IVM....

GUIDANCE on policy-making for Integrated Vector Management [WHO] — (English)
This document is meant to guide people in an advisory or decision-making role in formulating policy on the control of vector-borne diseases. It was prepared at the same time as a handbook on integrated vector management (IVM), which contains background information and lays out a comprehensive operational framework for IVM....

HANDBOOK for Integrated Vector Management [WHO] — (English)
The intention of this handbook on integrated vector management (IVM) is to provide guidance to the managers of vector-borne disease control programmes, including comparable officials in health and other sectors involved in vector-borne disease control....

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Articles requiring subscription

UN Envoy's response to estimates of global malaria mortality [The Lancet, Volume 379, Issue 9817, Pages 707 - 708, 25 February 2012] — (English)
Using different methodologies, Murray and colleagues1 confirmed the earlier report by WHO3 that worldwide fatalities from malaria decreased by nearly a third between 2004 and 2010. By contrast with the agreement on the slope of the downward trend, Murray and colleagues' new estimate of the absolute number of annual deaths from malaria is almost twice as large as WHO's estimate, and includes a striking and unexpected number of deaths among adults and older children...

PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium [PNAS 10.1073/pnas.1121567109] — (English)
PK4 activity leads to the arrest of global protein synthesis in schizonts, where ontogeny of daughter merozoites takes place, and in gametocytes that infect Anopheles mosquitoes...

Intravenous Ferric Carboxymaltose Accelerates Erythropoietic Recovery From Experimental Malarial Anemia [J Infect Dis. (2012) doi: 10.1093/infdis/jis020] — (English)
Our findings challenge the restrictive use of iron therapy in malaria and show the need for trials of intravenous ferric carboxymaltose as an adjunctive treatment for severe malarial anemia...

Drug treatment of malaria infections can reduce levels of protection transferred to offspring via maternal immunity [10.1098/rspb.2011.1563 Proc. R. Soc. B] — (English)
This study reveals the role that within-host infection dynamics play in the fitness consequences of maternally transferred immunity. Furthermore, it highlights a potential trade-off between the health of mothers and offspring suggesting that anti-parasite treatment may significantly affect the outcome of infection in newborns...

RTS,S/AS01 Malaria Vaccine in African Children [N Engl J Med 2012; 366:764-766 February 23, 2012] — (English)
Letter to the Editor...

RTS,S/AS01 Malaria Vaccine in African Children [N Engl J Med 2012; 366:764-765 February 23, 2012] — (English)
Author reply...

Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children [Clin Infect Dis. (2012) doi: 10.1093/cid/cis010] — (English)
Malaria risk is influenced by physiologic iron status, and therefore iron supplementation may have adverse effects even among children with ID. Future interventional studies should assess whether treatment for ID coupled with effective malaria control can mitigate the risks of iron supplementation for children in areas of malaria transmission...

Iron Deficiency and Severe Plasmodium falciparum Malaria [Clin Infect Dis. (2012) doi: 10.1093/cid/cis020] — (English)
With regard to Fe deficiency/supplementation in the face of infection with malaria, various conflicting disease outcomes have been reported from different studies...

Mixed Vector Immunization With Recombinant Adenovirus and MVA Can Improve Vaccine Efficacy While Decreasing Antivector Immunity [Molecular Therapy (2012); doi:10.1038/mt.2012.25] — (English)
We investigated whether the two vaccine components adenovirus (Ad) and MVA could be coinjected as a mixture to enhance protection against malaria...

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter [Antimicrob. Agents Chemother. AAC.00166-12] — (English)
Our data demonstrate that saquinavir behaves as a CQ ‘resistance-reverser’, and that this explains, at least in part, its ability to enhance the effects of CQ in CQ-resistant P. falciparum parasites...

Cytogenetic status of human lymphocytes after exposure to low concentrations of p,p'-DDT, and its metabolites (p,p'-DDE, and p,p'-DDD) in vitro [Chemosphere, Available online 20 February 2012] — (English)
Despite that the use of DDT has been restricted for more than 40 years to malaria affected areas, low doses of this pesticide and its metabolites DDE and DDD can be found in the environment around the world...

DNA barcoding reveals both known and novel taxa in the Albitarsis Group (Anopheles: Nyssorhynchus) of Neotropical malaria vectors [Parasites & Vectors 2012, 5:44 doi:10.1186/1756-3305-5-44] — (English)
DNA barcoding provides a reliable means of identifying both known and undiscovered biodiversity within the closely related taxa of the Albitarsis Group. We advocate its usage in future studies to elucidate the vector competence and respective distributions of all eight species in the Albitarsis Group and the novel mitochondrial lineage (An. albitarsis H) recovered in this study...

Inferring the evolutionary history of Indian Plasmodium vivax from population genetic analyses of multilocus nuclear DNA fragments [Molecular Ecology, DOI: 10.1111/j.1365-294X.2012.05480.x] — (English)
All these observations clearly indicate that Indian P. vivax presents complex evolutionary history but possesses several features of being a part of ancestral distribution range of this species...

Quantification of Plasmodium falciparum malaria from complex infections in the Peruvian Amazon using quantitative PCR of the merozoite surface protein 1, block 2 (PfMSP1-B2): in vitro dynamics reveal density-dependent interactions [Parasitology] — (English)
We compared 3 PfMSP1-B2 genotyping methods by analysing 79 field isolates from the Peruvian Amazon...

Role of the Helical Structure of the N-Terminal Region of Plasmodium falciparum Merozoite Surface Protein 2 in Fibril Formation and Membrane Interaction [Biochemistry. 2012 Feb 21;51(7):1380-7] — (English)
Our data suggest that partially folded helical conformations of the N-terminal region of MSP2 are on the pathway to amyloid fibril formation, while higher degrees of helical structure stabilized by high concentrations of TFE or membrane mimetics suppress self-association and thus inhibit fibril formation. The roles of the induced helical conformations in membrane interactions are also discussed...

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5 [Vaccine. 2012 Feb 21;30(9):1583-93] — (English)
The present study points to the importance of investigating whether biased geographical distribution for SNPs and repeat variants in the OR and SR regions affect the reactivity of human serum antibodies to variants...