6.02.2012

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Announcements / Press Releases

RBM's advocates huddle around a strategy to keep malaria on the global agenda [RBM MAWG] — (English)
RBM advocates and members of the RBM Partnership's Malaria Advocacy Working Group are gathering in London today to identify opportunities for malaria advocacy and prioritize key activities that organizations within RBM could jointly undertake in 2012...

7th Vector Control Working Group (VCWG) meeting [RBM VCWG] — (English)
Member of the RBM Vector Control Working Group have gathered for their 7th Annual Meeting to discuss urgent and emerging issues and establish a work plan for 2012...

Health actors get training on resource mobilisation for malaria [RBM] — (English)
Against the backdrop of diminishing financing for global health and at a time when malaria-endemic countries scale-up their efforts to meet the 2015 MDGs, members of the malaria community gathered in London to participate in a training, focused on the current funding landscape and opportunities. The event, organised by the Roll Back Malaria Partnership, featured a session on the funding mechanism of the World Bank's International Development Association (IDA). Guest speakers include representatives of the African Union Commission, the Office of the UN Secretary General's Special Envoy for Malaria and the African Leaders Malaria Alliance...

Why are malaria mortality rates different in recent studies? [WHO Q&A online] — (English)
WHO stands by their previous estimates that were based on the methodology developed by the UN agency in collaboration with other partners. WHO welcomes the Institute for Health Metrics and Evaluation's estimates that actually show more similarities than differences. Both approaches show that an unacceptably high number of people still die from malaria. The trends in disease are steadily downward by both methods, thanks to investments in scaling up life-saving tools...

A decade of European support to the Global Fund [The Global Fund] — (English)
Friends of the Global Fund Europe, the Global Fund and its partners held a meeting to commemorate 10 years of partnership with the Global Fund for more impact. Friends of the Global Fund Europe, an advocacy organization that helps mobilize support in the fight against the three deadly diseases, co-hosted this meeting with the Global Fund, with the support of the Foreign Ministry of Foreign Affairs of France, the Mairie de Paris, the International Herald Tribune and Sanofi...

President Ellen Johnson Sirleaf Named Chair of African Effort to End Malaria Deaths [ALMA] — (English)
Recent Nobel Prize laureate, President Ellen Johnson Sirleaf of Liberia, today assumed the chair of the African Leaders Malaria Alliance (ALMA) from President Jakaya Mrisho Kikwete of the United Republic of Tanzania. President Armando Guebuza of Mozambique was elected Deputy Chair of ALMA...

Me and My Net Winners [Me and My Net] — (English)
We were delighted to receive over 2000 entries to the Me and My Net Competition, from 25 different Commonwealth countries. The judges were impressed by the passion and inventiveness shown by entrants and had difficult decisions to make deliberating over the 225 awards and certificates - so, well done to everyone who took part!...

East Africa Regional Liaison Scientist (Reference Number: EARLS-01-12 ) [WWARN] — (English)
View job description on the KEMRI-Wellcome Trust web site...

Business Development and Legal Assistant [MMV] — (English)
View job description on the MIM web site...

Health Policy Action Fund : Call for Proposals [HPAF] — (English)
View job description on the HPAF website Proposals can be sent to cjacob@oxfam.org.uk...

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Articles requiring subscription

New estimates of malaria deaths: concern and opportunity [The Lancet, Volume 379, Issue 9814, Page 385, 4 February 2012 doi:10.1016/S0140-6736(12)60169-X] — (English)
This week we publish surprising and, on the face of it, disturbing findings. According to Christopher Murray and colleagues at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington in Seattle, there were 1·24 million deaths (95% uncertainty interval 0·93—1·69 million) from malaria worldwide in 2010—around twice the figure of 655 000 estimated by WHO for the same year. How should the malaria community interpret this finding? Before we answer that question, we need to look beneath the surface of this striking overall mortality figure...

Global malaria mortality between 1980 and 2010: a systematic analysis [The Lancet, Volume 379, Issue 9814, Pages 413 - 431, 4 February 2012 doi:10.1016/S0140-6736(12)60034-8] — (English)
We systematically collected all available data for malaria mortality for the period 1980—2010, correcting for misclassification bias. We developed a range of predictive models, including ensemble models, to estimate malaria mortality with uncertainty by age, sex, country, and year. We used key predictors of malaria mortality such as Plasmodium falciparum parasite prevalence, first-line antimalarial drug resistance, and vector control. We used out-of-sample predictive validity to select the final model...

Performance of Two Malaria Rapid Diagnostic Tests in Febrile Adult Patients with and without Human Immunodeficiency Virus-1 Infection in Blantyre, Malawi [Am J Trop Med Hyg 2012 86:199-202; doi:10.4269/ajtmh.2012.11-0350] — (English)
The performance of two histidine-rich protein type-2–based malaria rapid diagnostic tests (mRDTs) was examined in a rural area with a high prevalence of malaria and human immunodeficiency virus type-1 (HIV-1) infection in 113 and 445 febrile patients...

Compliance, Safety, and Effectiveness of Fixed-Dose Artesunate-Amodiaquine for Presumptive Treatment of Non-Severe Malaria in the Context of Home Management of Malaria in Madagascar [Am J Trop Med Hyg 2012 86:203-210; doi:10.4269/ajtmh.2012.11-0047] — (English)
This study provides comprehensive data concerning the clinical cure rate obtained with artesunate-amodiaquine and evidence supporting the scaling up of home management of malaria...

False-Negative Rapid Diagnostic Tests for Malaria and Deletion of the Histidine-Rich Repeat Region of the hrp2 Gene [Am J Trop Med Hyg 2012 86:194-198; doi:10.4269/ajtmh.2012.10-0665 ] — (English)
These findings suggest that the use of HRP2-based RDTs should be reconsidered...

How Do We Best Diagnose Malaria in Africa? [Am J Trop Med Hyg 2012 86:192-193; doi:10.4269/ajtmh.2012.11-0619] — (English)
For many decades, the cornerstone of malaria management in Africa was to treat all febrile children with chloroquine...

Different Patterns of pfcrt and pfmdr1 Polymorphisms in P. falciparum Isolates from Nigeria and Brazil: The Potential Role of Antimalarial Drug Selection Pressure [Am J Trop Med Hyg 2012 86:211-213; doi:10.4269/ajtmh.2012.11-0368] — (English)
Continuous monitoring of pfcrt SVMNT haplotype is required in endemic areas of Africa, where artesunate-amodiaquine combination is used for treatment of acute uncomplicated malaria...

Molecular markers for detection and differentiation of Plasmodium falciparum and Plasmodium vivax in human blood samples by pyrosequencing [JCM.06001-11 2012, doi: 10.1128] — (English)
PCR amplification coupled with pyrosequencing was used to measure molecular markers that could be used to detect and differentiate Plasmodium falciparum and Plasmodium vivax in human blood samples.The detection rates were in agreement with Giemsa-stained film microscopy, which is the current gold standard for detection. This method provides an exciting alternative for malaria diagnosis...

Malaria's deadly secret: a skin stage [Trends in Parasitology, 02 February 2012 10.1016/j.pt.2012.01.002] — (English)
The role skin plays in malaria infection has long been overlooked. Recent analysis, however, suggests skin-infecting sporozoites initiate rapid suppression of immunity, establishing early tolerance to subsequent lifecycle stages...

Improving Cognitive Outcome in Cerebral Malaria: Insights from Clinical and Experimental Research [Central Nervous System Agents in Medicinal Chemistry(Formerly Current Medicinal, Volume 11, Number 4, December 2011, pp. 285-295(11)] — (English)
This review discusses clinical aspects of cognitive sequelae, possible mechanisms involved in the brain injury, perspectives and limitations regarding the pharmacological strategies to improve cognitive outcome in CM...

Molecular screening of Plasmodium infections among migrant workers in Thailand [J Vector Borne Dis 48, December 2011, pp. 214–218] — (English)
A cross-sectional study was conducted to determine the prevalence of Plasmodium infections among migrant workers in Thailand...

Preliminary characterization of N-trimethylchitosan as a nanocarrier for malaria vaccine [J Vector Borne Dis 48, December 2011, pp. 224–230] — (English)
With the current snags from the use of Artemisinin-combination therapies (ACTs) in malaria treatment in addition to fear of cross-resistance to unrelated drugs, raising the immunocompetence of individuals in malaria endemic areas by vaccination is the best approach to malaria-free world...

Plasmodium vivax malaria presenting with skin rash [J Vector Borne Dis 48, December 2011, pp. 245–246] — (English)
A case report...

Spontaneous acute subdural hematoma in malaria [J Vector Borne Dis 48, December 2011, pp. 247–248] — (English)
A case report...

Pratiques agricoles et épidémiologie du paludisme en zone soudano-sahélienne du Cameroun [Bulletin de la Société de pathologie exotique Volume 105, Number 1, 23-29, DOI: 10.1007/s13149-011-0202-4 ] — (Article in French)
We have comparatively studied the dynamics of malaria transmission in the villages of Mokolo-Douvar located in the rural area with traditional agriculture and Gounougou irrigated rice area, in 2004 August and November and 2006 May and October, to assess vectors biting habits, and malaria inoculation rate and malaria parasite prevalence in cohort of children from 0 to 15 years...

Supraorbital Postmortem Brain Sampling for Definitive Quantitative Confirmation of Cerebral Sequestration of Plasmodium falciparum Parasites [J Infect Dis. (2012) doi: 10.1093/infdis/jis001] — (English)
We have assessed the use of a cytological smear of brain tissue, obtained post-mortem by supraorbital sampling, for the purpose of quantifying cerebral sequestration in children with fatal malaria in Blantyre, Malawi. We have compared this method to histological quantification of parasites at autopsy...

The association between Haptoglobin and Heme Oxygenase-1 genetic profiles and sCD163 in the susceptibility to and severity of human malaria [IAI.05933-11 doi: 10.1128/​IAI.05933-11] — (English)
We found that long (GT)n repeats in the microsatellite polymorphism region of the HMOX1 gene, the Hp2 allele and the Hp2.2 genotype were associated with symptomatic malaria...

A NEW MORPHOLOGICALLY DISTINCT AVIAN MALARIA PARASITE THAT FAILS DETECTION BY ESTABLISHED PCR-BASED PROTOCOLS FOR AMPLIFICATION OF THE CYTOCHROME B GENE [Journal of Parasitology] — (English)
We suggest possible explanations of these results and call for additional research on evolution of mitochondrial genome of hemosporidian parasites...

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics [Cellular and Molecular Life Sciences DOI: 10.1007/s00018-011-0906-0] — (English)
We examine a number of the antimalarial strategies currently undergoing development that are designed to exploit the resistance mechanism, including relatively simple measures, such as alternative CQ dosages, as well as new drugs that either circumvent the resistance mechanism or target it directly...

The challenge of malaria eradication in the twenty-first century: Research linked to operations is the key [Vaccine] — (English)
Interest and support for malaria control, eradication, and research has increased greatly over the past decade...