10.03.2008
The Gates Foundation Grants 200 million to Malaria Research and Control Programs [B&M Gates Foundation] — (English)
The Bill & Melinda Gates Foundation recently awarded 13 new grants, totaling almost US $200 million, to help fight malaria...
"Joining Forces, Synergising Action – Sustainable and Innovative Ways of Ensuring Long-Term Availability of Malaria Prevention and Treatment Measures by 2015" [Deutsche Welle] — (English)
Invitation to an International Conference...
Gain And Loss In Malaria War [Chemical and Engineering News - USA] — (English)
Ambitious ventures launch as GSK pulls two treatments for the disease...
Zimbabwe: Join Hands in Fighting Malaria [The Herald (Harare)] — (English)
Despite the advent of the HIV virus, malaria remains the biggest potential killer in Africa; only modern prevention methods and the discovery of a range of curative drugs hold the horror at bay...
Government maps areas hit by malaria [GIS Developement - USA] — (English)
National Vector-Borne Disease Control Programme (NVBDCP) after almost three months of extensive research, and using GIS has brought out the country's first malaria map, to identify populations most at risk...
No miRNA were found in Plasmodium and the ones identified in erythrocytes could not be correlated with infection [Malaria Journal 2008, 7:47 (10 March 2008)] — (English)
This paper confirms the absence of miRNA in Plasmodium...
9.03.2008
Cold War, Deadly Fevers: Malaria Eradication in Mexico 1955–1975 [EID Journal, Volume 14, Number 3–March 2008] — (English)
Marcos Cueto is a medical historian who describes the details of malaria eradication efforts in Mexico in the context of the Cold War era authoritarianism. His approach works overall, but occasionally he overreaches...
Parasites and Infectious Diseases: Discovery by Serendipity and Otherwise [EID Journal, Volume 14, Number 3–March 2008] — (English)
The author of this book retells several of the famous stories of discovery in the field of vector-borne and parasitic diseases through the eyes of some of the most prominent researchers working in this field today. But Esch does not stop there—he goes on to connect these early stories with more recent watershed contributions as recounted through a series of interviews he references throughout the course of the book. For example, he describes the discovery of the African sleeping sickness agent, Trypanosoma gambiense, and the contributions in the early 1900s by Dutton, Castellani, and Bruce. He then moves on to more recent discoveries regarding immunity, antigenic variation, and the role of variable surface glycoproteins. He describes the seminal studies that were performed in this area as recounted through interviews with prominent parasitologists Dick Seed and Keith Vickerman. Through this process, Esch weaves a tapestry of the new and old as it relates to the history of important tropical diseases such as African typanosomiasis, malaria, yellow fever, HIV/AIDS, hookworm, and schistosomiasis, which continue to plague humankind...
Biodiversité du paludisme dans le monde [ISBN : 2-7420-0452-1] — (English translation from French)
A million deaths every year, 500 million sufferers, 2 billion people at risk: those were the figures concerning malaria in 2000.
The distribution and seriousness of the disease vary according to pathogenic agents, vectors and the environment.
At the present time, 90% of deaths from the strain of malaria caused by P. falciparum affect tropical Africa, where only 10% of the world's population lives. The African continent is home to the most efficient vectors and the climate is eminently favourable to transmission of the disease.
Serious outbreaks also occur in the wooded regions of South-East Asia, New Guinea and Amazonia. Elsewhere in the tropical and subtropical world, the strain of malaria caused by P. vivax and/or P. malariae is less severe.
This book describes 50 years of active struggle against malaria, a succession of periods of euphoria followed by periods of depression that have not shaken researchers' belief that the scourge of malaria can be eliminated...
Uganda: Ministry Delays DDT Spraying [New Vision (Kampala)] — (English)
INDOOR residual spraying of DDT has been delayed due to administrative issues...
8.03.2008
Malaria no More [Deutsche Welle - Germany] — (Deutsch)
Jährlich sterben bis zu drei Millionen Menschen an Malaria und ihren Folgen, die meisten davon in Afrika. In Berlin sammelt der gemeinnützige Verein Malaria No More Deutschland Geld für Anti-Malaria-Projekte in Afrika...
Compassion International and top Christian singer issue call for help fighting malaria [Assist News - USA] — (English)
Dr. Wess Stafford, president of Compassion International, and recording artist Rebecca St. James issued a passionate appeal Saturday for people to join the fight against malaria...
Zimbabwe: Govt Extends Malaria Spraying Programme [The Herald (Harare)] — (English)
Govenmenr has extended the duration of malaria spraying programme owing to the prolonged rains and flooding which made some areas inaccessible because of damaged roads...
Sénégal: Après les pluies hors-saison à Saint-Louis - le programme contre le paludisme fait le point [Le Soleil (Dakar)] — (Français)
Une mission du Programme national de lutte contre le paludisme a séjourné à Saint-Louis, dans le but de faire le point sur les risques de recrudescence du paludisme, après les pluies hors-saison qui se sont abattues dans la région...
7.03.2008
Tycoon gives £15m malaria grant [BBC News - UK] — (English)
Scientists have been given a $30m (£15.1m) grant by Microsoft tycoon Bill Gates to improve the treatment and control of malaria in pregnancy...
A discovery that could make malaria easier to treat [Radio Prague - Prague,Czech Republic] — (English)
Czech scientists and their Australian colleagues recently made a unique discovery which should contribute to the development of medication against malaria, making it easier to produce, safer and cheaper. The results of their study were recently published in the prestigious Nature magazine. Ruth Fraňková spoke to a member of the Czech team, Jan Janouškovec, to find out what kind of progress has been made...
Vietnam to spend $4.7 mln on malaria prevention [Thanh Nien Daily - Ho Chi Minh City,Vietnam] — (English)
The Vietnamese government will fund VND75 billion (US$4.7 million) to prevent and fight malaria this year, announced the Ministry of Public Health at a recent conference on malaria...
MDS PHARMA SERVICES WINS AWARD FOR MANAGEMENT OF GLOBAL MALARIA TRIAL [What's new in Pharma - UK] — (English)
MDS Pharma Services, a leading provider of innovative drug discovery and development solutions, has won the Good Clinical Practice Journal (GCPj) Award for the clinical research program that best promotes access to new medicines. This award is one of a series of inaugural GCPj awards introduced this year to recognize excellence in clinical research. MDS Pharma Services received this award during a ceremony in London where it was recognized for its successful management of a large-scale Phase III malaria drug trial involving more than 2,700 patients in Laos, India, Thailand, Burkina Faso, Kenya, Mozambique, Uganda, and Zambia...
Patients query new Malaria drug [AfricaNews] — (English)
Some patients who are on Malaria treatment in Malawi, have complained of persistent headaches and itching whilst others have said some parts of their bodies swell after taking the the newly introduced drug known as artemisinin combination therapy(ACT) commonly known as LA...
Cameroun: Bilan mitigé pour Roll-Back Malaria [Cameroon Tribune (Yaoundé)] — (Français)
Sous consommation du budget, prise en charge et distribution de la moustiquaire imprégnée moyennes Tout n'a pas été parfait pour ce comité...
A highly conserved segmental duplication in the subtelomeres of Plasmodium falciparum chromosomes varies in copy number [Malaria Journal 2008, 7:46 (7 March 2008)] — (English)
The subtelomeric regions of the 14 chromosomes are species-specific, highly polymorphic and consist of a patchworks of repetitive blocks. Many families of variable genes, including var genes, are located in this regions...
6.03.2008
Zambia sets an example in malaria control [SciDev.net - UK] — (English)
Zambia is improving its measures to combat malaria and seeks to set an example for tackling the disease in remote rural areas...
Good News: Karlo Will Live [NYT - USA] — (English)
The farm families living in these rocky hills in central Sudan confront every disease imaginable, from leprosy to malaria, and perhaps one-quarter of children die by the age of five...
Namibia: Strong Emphasis On Social Safety Net [New Era (Windhoek)] — (English)
The 2008/9 national budget tabled by Finance Minister Saara Kuugongelwa-Amadhila is considered an "extreme expenditure" budget characterised by its strong emphasis on improving the social safety net, the development of human capital and investment for competitiveness...
Youth raise $5000 to fight malaria [Arlington Advocate - Lexington,MA,USA] — (English)
The youth of Calvary Church, United Methodist raised thousands of dollars in the fight against malaria in Africa ...
Sénégal: Lutte contre le paludisme - Les bons points de l'aspersion intra domiciliaire [Le Soleil (Dakar)] — (Français)
Les autorités administratives et sanitaires du département de Dagana ont lancé officiellement, lundi dernier à Rosso-Sénégal, dans le cadre de la lutte contre le paludisme, les activités d'aspersion intra domiciliaires soutenues par le peuple américain...
More malaria cases [radiojamaica.com - Jamaica] — (English)
New cases of malaria have surfaced in Jamaica...
5.03.2008
Lending a Helping Arm: Volunteers Risk Malaria to Test Vaccine [Scientific American - USA] — (English)
Volunteers in Seattle chance getting the disease in a bid to defeat it...
You can get paid to catch malaria [Seattle Times - USA] — (English)
Seattle-area residents will soon be able to go all the way: allowing themselves to be bitten by malaria-infected mosquitoes to aid in the quest for new vaccines and drugs...
PATH-SBRI to establish human testing centre for malaria vaccines [Pharma Times - London,UK] — (English)
The PATH Malaria Vaccine Initiative (MVI), the US-based global development programme set up in 1999 with initial backing from the Bill & Melinda Gates Foundation, has announced a new collaboration with Seattle Biomedical Research Institute (SBRI) that could hasten the clinical assessment of malaria vaccine candidates...
Surveillance the secret weapon against malaria [SciDev.Net - UK] — (English)
The global anti-malaria effort is running without regional monitoring, laboratory and surveillance networks, says Mark Grabowsky in Nature...
Saving lives by distributing free mosquito nets in Guinea-Bissau [UNICEF] — (English)
Awa Gras knows firsthand how deadly malaria can be for children growing up in Guinea-Bissau. She has given birth to eight children, and malaria has killed four of them. The last to die was her four-year-old son, who returned from a soccer match feeling ill...
SAUDI ARABIA-YEMEN: Anti-malaria campaign targets border areas [IRINNEWS] — (English)
An extensive Saudi-Yemeni campaign to combat malaria began on 3 March in three Yemeni provinces near the border with Saudi Arabia, with the aim of reducing malaria in those areas...
Open-Label Comparative Clinical Study of Chlorproguanil−Dapsone Fixed Dose Combination (Lapdap™) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria [PLOS One] — (English)
CPG–DDS plus artesunate demonstrated advantages over CPG–DDS alone for the primary efficacy endpoint (mean time to PC90) except in children for the 1 mg/kg artesunate dose. Based on a pre-defined decision matrix, the primary endpoint in the child group supported an artesunate dose of 4 mg/kg. Secondary endpoints also supported a 4 mg/kg artesunate dose to take forward into the remainder of the development program...
Identification and Characterization of a Novel Plasmodium falciparum Merozoite Apical Protein Involved in Erythrocyte Binding and Invasion [PLOS One] — (English)
Proteins that coat Plasmodium falciparum merozoite surface and those secreted from its apical secretory organelles are considered promising candidates for the vaccine against malaria. In the present study, we have identified an asparagine rich parasite protein (PfAARP; Gene ID PFD1105w), that harbors a predicted signal sequence, a C-terminal transmembrane region and whose transcription and translation patterns are similar to some well characterized merozoite surface/apical proteins...
Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species [Malaria Journal 2008, 7:45 (5 March 2008)] — (English)
Easy-to-use technique to enrich schizonts and gametocytes from peripheral blood of infected patients: particularly useful for the concentration of non-falciparum species, which do not grow in culture and are otherwise difficult to obtain in large amounts...
Part of the Team: Sedge Garden Methodist joins push to fight malaria in Africa [Winston-Salem Journal - Winston-Salem,NC,USA] — (English)
Sedge Garden United Methodist Church has joined with the National Basketball Association, Sports Illustrated magazine and United Methodist Men nationwide to sponsor a “Nothing but Nets” fundraiser...
Uganda: New Global Fund Proposal Underway [The Monitor (Kampala)] — (English)
IF Uganda can beat the July 1 deadline, the country stands a chance to get millions of dollars the Global Fund has earmarked to fight Aids, Tuberculosis and Malaria under its Round 8 programme...
4.03.2008
Newly Developed Anti-malarial Medicine Treats Toxoplasmosis [Science Daily (press release) - USA] — (English)
A new drug that will soon enter clinical trials for treatment of malaria also appears to be 10 times more effective than the key medicine in the current gold-standard treatment for toxoplasmosis, a disease caused by a related parasite that infects nearly one-third of all humans--more than two billion people worldwide...
Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo [PLOS Neglected Tropical Diseases] — (English)
Toxoplasma gondii causes substantial morbidity, mortality, and costs for healthcare in the developed and developing world. Current medicines are not well tolerated and cause hypersensitivity reactions. The dihydrotriazine JPC-2067-B (4, 6-diamino-1, 2-dihydro-2, 2-dimethyl-1-(3′(2-chloro-, 4-trifluoromethoxyphenoxy)propyloxy)-1, 3, 5-triazine), which inhibits dihydrofolate reductase (DHFR), is highly effective against Plasmodium falciparum, Plasmodium vivax, and apicomplexans related to T. gondii. JPC-2067-B is the primary metabolite of the orally active biguanide JPC-2056 1-(3′-(2-chloro-4-trifluoromethoxyphenyloxy)propyl oxy)- 5-isopropylbiguanide, which is being advanced to clinical trials for malaria. Efficacy of the prodrug JPC-2056 and the active metabolite JPC-2067-B against T. gondii and T. gondii DHFR as well as toxicity toward mammalian cells were tested...
New Global Malaria Map [Voice of America - USA] — (English)
Malaria, once thought to be almost eradicated, is on the rise again, and a new map shows just how far and how fast it's spreading. Rose Hoban reports...
Eradicate Malaria? Doubters Fuel Debate [New York Times - United States] — (English)
Last year, challenging global health orthodoxy, Bill and Melinda Gates called for the eradication of malaria...
JHMRI Hosts 4th International Malaria Research Conference [Newswise - USA] — (English)
The Johns Hopkins Malaria Research Institute is hosting its Fourth International Research Conference at the Johns Hopkins Bloomberg School of Public Health in Baltimore, Md. March 17-18. The two-day conference will explore the latest developments from many fields of malaria research, including discussions of malaria parasite genetics and strategies for controlling mosquitoes without insecticides...
Farmers rake millions from malaria drug [Monitor - Uganda] — (English)
There is growing demand for Artemesinin as leading pharmaceuticals take on
the manufacture of Artemesinin-based drugs...
Malaria: NetsforLife brings succour to Nigerians [Vanguard - Nigeria] — (English)
HISTORY was made in Nigeria Thursday last week when the NetsforLife Initiative to fight malaria was officially launched in Abuja. It was the climax of the expansion of an international programme with the objective of distributing long-lasting insecticide-treated nets to Nigerian communities with a high prevalence of reported malaria cases...
Soccer-Roundup-Cameroon's Tomou contracts malaria [Reuters.uk - UK] — (English)
Cameroon striker Bertin Tomou is the second player to contract malaria following the African Nations Cup finals in Ghana and was hospitalised at the weekend, his Belgian club said on Wednesday...
Fae in malaria scare [Reading Evening Post - Reading,England,UK] — (English)
EMERSE FAE missed Reading’s victory at Middlesbrough on Saturday after being struck down by malaria...
Articles requiring subscription
New antimalarial targets: The example of glucose transport [Transactions of the Royal Society of Tropical Medicine and Hygiene, In Press, Corrected Proof, Available online 6 March 2008] — (English)
We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine + sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda...
Tolérance et efficacité de l’atovaquone-proguanil dans le traitement du paludisme d’importation à Plasmodium falciparum de l’enfant en France métropolitaine : expérience d’un centre hospitalier parisien> [Archives de Pédiatrie, In Press, Corrected Proof, Available online 5 March 2008] — (Français)
Chez l’enfant, peu de traitements sont disponibles pour les accès palustres d’importation non compliqués à Palciparum falciparum. L’atovaquone-proguanil (Malarone®) est un antimalarique récent utilisé dans le traitement des accès palustres simples de l’adulte. Chez l’enfant, quelques essais menés en zone d’endémie sont disponibles, mais aucune étude n’a été conduite dans le cadre du paludisme d’importation...
Dihydrofolate reductase I164L mutations in Plasmodium falciparum isolates: clinical outcome of 14 Kenyan adults infected with parasites harbouring the I164L mutation [Transactions of the Royal Society of Tropical Medicine and Hygiene, In Press, Corrected Proof, Available online 5 March 2008] — (English)
Recently, Plasmodium falciparum bearing dihydrofolate reductase (DHFR) I164L was isolated from Africa. Quadruple mutations containing I164L confer high-level resistance to antifolate antimalarials. We prospectively measured the effect of co-trimoxazole (CTX) prophylaxis on P. falciparum antifolate resistance development among HIV-infected persons...
Performance and reliability of the SYBR Green I based assay for the routine monitoring of susceptibility of Plasmodium falciparum clinical isolates [Transactions of the Royal Society of Tropical Medicine and Hygiene, In Press, Corrected Proof, Available online 5 March 2008] — (English)
The performance and the reliability of a SYBR Green I fluorescence-based assay to assess drug susceptibility in routine monitoring were evaluated in 138 Plasmodium falciparum clinical samples. Blood samples were studied for susceptibility to four antimalarial drugs by the SYBR Green I based assay, with the traditional [3H]-hypoxanthine isotopic assay as a reference...
Plasmodium falciparum multiple infections, disease severity and host characteristics in malaria affected travellers returning from Africa [Travel Medicine and Infectious Disease, In Press, Corrected Proof, Available online 5 March 2008] — (English)
In our study all but one patients with severe malaria had a infection with a multiplicity of P. falciparum clones. At multivariate analysis the male gender, and the occurrence of severe malaria were significanly more commonly detected in patients affected by imported malaria with multiple clones...
Resonance Raman spectroscopy can detect structural changes in haemozoin (malaria pigment) following incubation with chloroquine in infected erythrocytes [FEBS Letters, In Press, Uncorrected Proof, Available online 4 March 2008] — (English)
Resonance Raman spectroscopy was applied to monitor the effects of chloroquine (CQ) treatment on cultures of Plasmodium falciparum trophozoites. A number of bands assigned to A1g and B1g modes characteristic of the haemozoin aggregate are reduced in intensity in the CQ-treated cells, however, no bands from the CQ are observed. The intensity changes are attributed to intermolecular drug binding of the CQ in a sandwich type complex between ferriprotoporphyrin IX (FePPIX) dimer units. It is postulated that the CQ binds via π–π interactions between adjacent and orientated porphyrins thereby disrupting the haemozoin aggregate and reducing excitonic interactions between adjacent haems. The results show the potential of Raman microscopy as a screening tool for FePPIX:drug interactions in live cells...
Management and prevention of imported Plasmodium falciparum malaria: Recommendations for clinical practice 2007 [Médecine et Maladies Infectieuses, In Press, Corrected Proof, Available online 4 March 2008] — (English)
Revision 2007 of the 1999 consensus conference...
Malaria transmission and rice cultivation in Lagdo, northern Cameroon [Transactions of the Royal Society of Tropical Medicine and Hygiene, In Press, Corrected Proof, Available online 4 March 2008] — (English)
Cross-sectional entomological surveys were carried out during the 2006 dry and rainy seasons in Lagdo, Cameroon to measure the impact of rice cultivation on malaria transmission and to monitor vector susceptibility to insecticides. Adult anopheline mosquitoes were captured on human volunteers and by pyrethrum spray collections...
kdr: can a single mutation produce an entire insecticide resistance phenotype? [Transactions of the Royal Society of Tropical Medicine and Hygiene, In Press, Corrected Proof, Available online 4 March 2008] — (English)
Knockdown resistance (kdr) is closely associated with DDT and pyrethroid resistance in the major malaria vector Anopheles gambiae and is considered to be causative of the resistance phenotype. The same association does not apply to Sudanese populations of the closely related malaria vector A. arabiensis. Speculation on this discrepancy and on the incidence of multiple insecticide resistance and cross-resistance has implications for the manner in which entomological surveys are conducted in the field as well as on the array of technologies employed to produce usable data...
Sécurité transfusionnelle : paludisme et don de sang en Afrique [Transfusion Clinique et Biologique, In Press, Corrected Proof, Available online 4 March 2008] — (Français)
Résumé
Le paludisme est une des causes principales de la mortalité infantile en Afrique, où son agent, le Plasmodium falciparum, représente une des infections majeures de transmissibilité transfusionnelle. Des études menées sur le continent africain ont apporté des données sur sa prévalence et ses facteurs de risque, sur ses manifestations cliniques chez le donneur de sang et sur les possibilités de prévention de la contamination transfusionnelle...
Malaria in African schoolchildren: options for control [Transactions of the Royal Society of Tropical Medicine and Hygiene, In Press, Corrected Proof, Available online 3 March 2008] — (English)
Intensified malaria control efforts among young African children may increase disease risks among older children who attend school and whose education may be impaired by malaria. However, there is currently no consensus as to the approach to malaria control in schools, with relevant intervention strategies varying according to patterns of malaria transmission...
The molecular evolution of four anti-malarial immune genes in the Anopheles gambiae species complex [BMC Evolutionary Biology 2008, 8:79] — (English)
We document varying levels of polymorphism within and divergence between the species, in all four genes. Introgression and the sharing of ancestral polymorphisms, two processes that have been documented in the past, were verified in this study in all four studied genes. These processes appear to affect each gene in different ways and to different degrees. However, there is no evidence of positive selection acting on these genes...
Plasmodium falciparum malaria vaccines in development [Expert Review of Vaccines, March 2008, Vol. 7, No. 2, Pages 223-240 ] — (English)
The development and implementation of a malaria vaccine would constitute a major breakthrough for global health. Recently, numerous new candidates have entered clinical testing, following strategies that are as diverse as the malaria cycle is complex...
Malaria overdiagnosis: is patient pressure the problem? [Health Policy and Planning Advance Access published online on March 4, 2008] — (English)
Patient demand was not found to be driving the over-prescription of antimalarials found in the hospitals in our setting. To the contrary, the involvement of patients may provide an opportunity to improve prescribing practice if their expectations for testing and treatment in line with test results can be effectively communicated to clinicians...
Characterization of a candidate locus for malaria susceptibility in human populations: a (TA)n microsatellite in the promoter region of the CYBB gene, the gp91 phox subunit of the NADPH oxidase [International Journal of Immunogenetics, Volume 35 Issue 2 Page 107-109, April 2008] — (English)
We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, previously associated with mild malaria. Thus, the candidate (TA)n microsatellite should be directly tested in genetic epidemiology studies...
ACRIDINEDIONES: SELECTIVE AND POTENT INHIBITORS OF THE MALARIA PARASITE MITOCHONDRIAL bc1 COMPLEX [Molecular Pharmacology Fast Forward. Published on March 4, 2008 as doi:10.1124/mol.108.045120] — (English)
Clinical treatment-failures to affordable drugs have contributed to a global increase in the number of deaths arising from malaria infection. This unacceptable situation has stimulated research for new drugs active against multi-drug resistant Plasmodium falciparum parasites...
Evolutionary analysis of genes of two pathways involved in placental malaria infection [Hum Genet. 2008 Mar 4] — (English)
Placental malaria is a special form of malaria that causes up to 200,000 maternal and infant deaths every year. Previous studies show that two receptor molecules, hyaluronic acid and chondroitin sulphate A, are mediating the adhesion of parasite-infected erythrocytes in the placenta of patients, which is believed to be a key step in the pathogenesis of the disease...
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia [Mol Med. 2008 Mar-Apr;14(3-4):89-97] — (English)
Plasmodium falciparum malaria causes 1–2 million deaths per year. Most deaths occur as a result of complications such as severe anemia and cerebral malaria (CM) (coma). Red cells of children with severe malaria-associated anemia (SMA) have acquired deficiencies in the complement regulatory proteins complement receptor 1 (CR1, CD35) and decay accelerating factor (DAF, CD55)...
Breadth and magnitude of antibody responses to multiple Plasmodium falciparum merozoite antigens are associated with protection from clinical malaria [Infect. Immun. doi:10.1128/IAI.01585-07] — (English)
Individuals living in malaria-endemic areas are repeatedly exposed to many different malaria parasite antigens. Studies on naturally-acquired antibody-mediated immunity to clinical malaria have largely focused on the presence of responses to individual antigens and their associations with decreased morbidity...
A Murine Model for Assessment of Plasmodium falciparum Transmission Blocking Vaccine using Transgenic Plasmodium berghei Parasites Expressing the target antigen Pfs25 [Infect. Immun. doi:10.1128/IAI.01409-07] — (English)
Currently, there is no animal model for Plasmodium falciparum challenge to evaluate malaria transmission blocking vaccines (TBV) based on well established Pfs25 target antigen...
Prepared in cooperation with WHO ANGOLA INFO.
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